merck millipore,默克密理愽
  • merck millipore,默克密理博,197224,Bcr-abl Inhibitor III, GNF-5 - Calbiochem

  • merck millipore,默克密理博,197224,Bcr-abl Inhibitor III, GNF-5 - Calbiochem

    产品名称：Bcr-abl Inhibitor III, GNF-5 - Calbiochem
    产品型号：197224
    The Bcr-abl Inhibitor III, GNF-5 controls the biological activity of Bcr-abl. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,197224,Bcr-abl Inhibitor III, GNF-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,197224,Bcr-abl Inhibitor III, GNF-5 - Calbiochem

    重要规格表

    经验配方
    C₂₀H₁₇F₃N₄O₃
    描述
    概述 A cell-permeable GNF-2 (Cat. No. 197221) N-hydroxyethyl carboxamide analog that exhibits in vivo efficacy in suppressing the proliferation of Bcr-abl-expressing Ba/F3 (93% and 83% of no-treatment control, respectively, on days 5 and 7 post treatment; 100 mg/kg b.i.d.) and bone marrow cells (~75% of no-treatment control in both WBC counts and spleen weight on day 7 post treatment; 50 mg/kg b.i.d.) in murine xenograft models of leukemia. Similar to GNF-2, GNF-5 exerts its effect via an allosteric mechanism (IC50 = 0.22 µM against wild-type Abl) by targeting the myristate-binding pocket near the c-terminus of Abl kinase domain and thereby altering the conformational dynamics of the ATP-binding pocket. GNF-5 is ineffective toward the myristate-binding site mutant E505K and the ATP-binding site ‘gatekeeper’ mutant T315I.
    产品目录编号 197224
    品牌系列 Calbiochem®
    同义词 N-(2-Hydroxyethyl)-3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide, Abl Inhibitor III
    参考
    参考 Zhang, J., et al. 2010. Nature 463, 501.
    产品信息
    形式 Off-white powder
    Hill配方 C₂₀H₁₇F₃N₄O₃
    化学配方 C₂₀H₁₇F₃N₄O₃
    Molar Mass 418.4
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,197224,Bcr-abl Inhibitor III, GNF-5 - Calbiochem

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