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merck millipore,默克密理博,MABT118,Anti-Desmoglein-1 Antibody, clone 32-2B
产品名称：Anti-Desmoglein-1 Antibody, clone 32-2B
产品型号：MABT118
Anti-Desmoglein-1, clone 32-2B detects levels of Desmoglein-1 proteins & has been published & validated for use in WB, IF, IHC & ICC.
merck millipore,默克密理博,MABT118,Anti-Desmoglein-1 Antibody, clone 32-2B
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ICC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MABT118 描述 Anti-Desmoglein-1 Antibody, clone 32-2B Alternate Names - Pemphigus foliaceus antigen
- Desmoglein-1
- Desmosomal glycoprotein 1
- DG1
- DGI
背景信息 Desmoglein-1 (DSG1) is a transmembrane glycoprotein belonging to the family of cadherins. It is one of the main structural components of desmosomal junctions which are abundant in tissues undergoing frequent mechanical stress, such as the heart, epidermis, lymphatic endothelial cells, and meninges. The desmoglein-1 subtype is highly expressed in the epidermis. Like other cadherins, desmoglein-1 contains multiple calcium binding sites and a cell-adhesion recognition site which facilitates intercellular adhesions. Desmoglein-1 is regulated by calcium and PKCα signaling, and is also coupled to intermediate filaments of the cytoskeleton. Desmosomes play a critical role in cell and tissue stability, and may contribute to the progression of cancer. 产品信息 格式 Purified 控制 - Human tonsil tissue lysate.
演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Desmoglein-1, clone 32-2B detects levels of Desmoglein-1 proteins & has been published & validated for use in WB, IF, IHC & ICC. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Desmoglein-1 in human tonsil tissues.
Immunofluorescence Analysis: A 1:1,000 dilution from a representative lot detected Desmoglein-1 in human tonsil tissues.
Western Blot Analysis: A representative lot from an independent laboratory detected Desmoglein-1 in bovine epidermal desmosomal cores and in human keratinocyte cell lysates. (Vilela, M. J., et al. (1995). J Cell Sci. 108(Pt 4):1743-1750.).
Immunofluorescent Analysis: A representative lot from an independent laboratory detected Desmoglein-1 in MDCK cells (Vilela, M. J., et al. (1995). J Cell Sci. 108(Pt 4):1743-1750.).
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Desmoglein-1 in human epidermal tissue (Maruani, A., et al. (2008). Am J Clin Pathol. 130(3):369-374.).生物信息 免疫原品种 Bovine Desmoglein-1 from nasal epidermis 克隆 32-2B 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2aκ 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. Predicted to react with Bovine based on immunogen design. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_776470
基因符号 - DSG1
纯化方法 Protein G purified UniProt编号 - Q03763
UniProt汇总 FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein by similarity. Cell junction > desmosome.
TISSUE SPECIFICTY: Epidermis, muzzle, tongue and esophagus.
DOMAIN: Calcium may be bound by the cadherin-like repeats.
SEQUENCE SIMILARITIES: Contains 4 cadherin domains.产品使用声明 质量保证 Evaluated by Western Blot in human tonsil tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Desmoglein-1 in 10 µg of human tonsil tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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