merck millipore,默克密理愽
  • merck millipore,默克密理博,420146,JAK3 Inhibitor VIII, NSC114792 - Calbiochem

  • merck millipore,默克密理博,420146,JAK3 Inhibitor VIII, NSC114792 - Calbiochem

    产品名称：JAK3 Inhibitor VIII, NSC114792 - Calbiochem
    产品型号：420146
    The JAK3 Inhibitor VIII, NSC114792 controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,420146,JAK3 Inhibitor VIII, NSC114792 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,420146,JAK3 Inhibitor VIII, NSC114792 - Calbiochem

    重要规格表

    经验配方
    C₂₆H₃₂N₄O₂S
    描述
    概述 A cell-permeable steroidal-purinethione that targets JAK3 kinase domain and selectively inhibits JAK3, but not JAK1, JAK2, or TYK2, activity and effectively blocks the constitutive Jak3 and STAT5 phosphorylations (complete inhibition at 10 µM) in BaF3-JAK3V674A and BLNK-/- BKO84 culltures. Shown to prevent the JAK3-dependent survival of L540, BaF3-JAK3WT, BaF3-JAK3V674A, and BLNK-/- BKO84 cells (by 40%, 50%, 57%, and 85%, respectively; 20 µM; 72 h), while exhibiting no effect against the JAK3-independent growth in DU145, HDLM-2, and MDA-MB-468 cultures.
    产品目录编号 420146
    品牌系列 Calbiochem®
    同义词 10,13-Dimethyl-17-(2-(6-sulfanylidene-3H-purin-9-yl)acetyl)-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one, Dimethyl-sulfanylidene-purinyl-acetyl-dodecahydrocyclopenta[a]phenanthren-3-one
    参考
    参考 Kim, B.H., et al. 2010. Mol. Cancer 9, 36.
    产品信息
    形式 Yellowish-white powder
    Hill配方 C₂₆H₃₂N₄O₂S
    化学配方 C₂₆H₃₂N₄O₂S
    Molar Mass 464.6
    结构配方图像
    生物信息
    纯度 ≥99% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,420146,JAK3 Inhibitor VIII, NSC114792 - Calbiochem

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