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  • merck millipore,默克密理博,AB5495-50UL,Anti-Potassium Channel Kir6.2 Antibody

  • merck millipore,默克密理博,AB5495-50UL,Anti-Potassium Channel Kir6.2 Antibody

    产品名称：Anti-Potassium Channel Kir6.2 Antibody
    产品型号：AB5495-50UL
    Anti-Potassium Channel Kir6.2 Antibody detects level of Potassium Channel Kir6.2 & has been published & validated for use in WB.

    merck millipore,默克密理博,AB5495-50UL,Anti-Potassium Channel Kir6.2 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5495-50UL,Anti-Potassium Channel Kir6.2 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5495-50UL
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Potassium Channel Kir6.2 Antibody
    产品信息
    格式 Affinity Purified
    控制
    • Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). For negative control, preincubate 1 μg of purified peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
    演示 Lyophilized from PBS, pH 7.4, containing 1% BSA and 0.025% sodium azide. Reconstitute with 50 μL of sterile distilled water. Centrifuge antibody preparation before use (10,000 x g for 5 min).
    应用
    应用 Anti-Potassium Channel Kir6.2 Antibody detects level of Potassium Channel Kir6.2 & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    应用说明 Western blotting: 1:200 using ECL on rat pancreas lysate.

    Immunohistochemistry on rat pancrease sections. Dilutions should be made using a carrier protein such as BSA (1-3%).

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Highly purified peptide corresponding to residues 372-385 of rat Kir6.2 (Accession P70673). The immunogen sequence is identical in mouse and conserved in human (12/14).
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes Kir6.2 (Inward rectifier potassium channel Kir6.2). The antibody does not react with Kir6.1. The epitope specific for Kir6.2 is not present in any other known proteins.
    品种反应性 Rat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000525.3
    Entrez基因汇总 Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM).
    基因符号
    • HHF2
    • KCNJ11
    • Kir6.2
    • MGC133230
    • BIR
    • IKATP
    • TNDM3
    • KIR6.2
    • PHHI
    UniProt编号
    • Q14654
    UniProt汇总 FUNCTION: SwissProt: Q14654 # This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity).
    SIZE: 390 amino acids; 43541 Da
    SUBUNIT: Associates with ABCC8/SUR.
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
    DISEASE: SwissProt: Q14654 # Defects in KCNJ11 are the cause of familial hyperinsulinemic hypoglycemia type 2 (HHF2) [MIM:601820]; also known as persistent hyperinsulinemic hypoglycemia of infancy (PPHI) or hyperinsulinism. HHF2 is the most common cause of persistent hypoglycemia in infancy and is due to defective negative feedback regulation of insulin secretion by low glucose levels. It causes nesidioblastosis, a diffuse abnormality of the pancreas in which there is extensive, often disorganized formation of new islets. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur. & Defects in KCNJ11 are a cause of permanent neonatal diabetes mellitus (PNDM) [MIM:606176]. PNDM is a rare form of diabetes characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. & Defects in KCNJ11 are the cause of transient neonatal diabetes mellitus type 3 (TNDM3) [MIM:610582]. Neonatal diabetes mellitus, defined as insulin-requiring hyperglycemia within the first month of life, is a rare entity. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes. In a significant number of patients with transient neonatal diabetes mellitus, diabetes type 2 appears later in life. The onset and severity of TNDM3 is variable with childhood-onset diabetes, gestational diabetes or adult-onset diabetes described. & Defects in KCNJ11 may contribute to non-insulin-dependent diabetes mellitus (NIDDM), also known as diabetes mellitus type 2.
    SIMILARITY: SwissProt: Q14654 ## Belongs to the inward rectifier-type potassium channel family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material at -20°C for up to 6 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µL

    merck millipore,默克密理博,AB5495-50UL,Anti-Potassium Channel Kir6.2 Antibody

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