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  • merck millipore,默克密理博,AB5603A4,Anti-Sox2, Alexa Fluor 488 Conjugate Antibody

  • merck millipore,默克密理博,AB5603A4,Anti-Sox2, Alexa Fluor 488 Conjugate Antibody

    产品名称：Anti-Sox2, Alexa Fluor 488 Conjugate Antibody
    产品型号：AB5603A4
    Detect Sox2 using this Anti-Sox2, Alexa Fluor 488 Conjugate Antibody validated for use in ICC.

    merck millipore,默克密理博,AB5603A4,Anti-Sox2, Alexa Fluor 488 Conjugate Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5603A4,Anti-Sox2, Alexa Fluor 488 Conjugate Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HICCRbAlexaFluor®488Polyclonal Antibody
    描述
    产品目录编号 AB5603A4
    描述 Anti-Sox2, Alexa Fluor® 488 Conjugate Antibody
    Alternate Names
    • Transcription factor SOX-2
    背景信息 SOX2 is also known as SRY related HMG BOX gene 2. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 and SOX3 show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse. These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution.
    产品信息
    格式 AlexaFluor®488
    控制
    • Undifferentiated ReNcell VM neural progenitor cells
    演示 Purified rabbit polyclonal conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
    应用
    应用 Detect Sox2 using this Anti-Sox2, Alexa Fluor 488 Conjugate Antibody validated for use in ICC.
    主要应用
    • Immunocytochemistry
    生物信息
    免疫原品种 Synthetic peptide from human Sox2.
    宿主 Rabbit
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with Human. Predicted to react with Mouse based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_003097
    Entrez基因汇总 This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
    基因符号
    • Sox2
    • SOX2
    纯化方法 Affinity purified
    UniProt编号
    • P48431
    UniProt汇总 FUNCTION: Can form ternary complexes with OCT-1 or OCT-3 but acts as a transcriptional activator of FGF-4 enhancer DNA sequences only in conjunction with OCT-3 (By similarity).

    SIZE: 317 amino acids; 34310 Da

    SUBCELLULAR LOCATION: Nucleus.

    DISEASE: Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. MCOPS3 is characterized by the association of microphthalmia or clinical anophthalmia with anomalies such as microcephaly, short stature, hypogonadotropic hypogonadism, esophageal atresia and neurologic manifestations.

    SIMILARITY: Contains 1 HMG box DNA-binding domain.
    产品使用声明
    质量保证 Evaluated by Immunocytochemistry in undifferentiated ReNcell VM neural progenitor cells.

    Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Sox2 in undifferentiated ReNcell VM neural progenitor cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB5603A4,Anti-Sox2, Alexa Fluor 488 Conjugate Antibody

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