merck millipore,默克密理愽
  • merck millipore,默克密理博,46-624MAG,MILLIPLEX MAP Phospho STAT3 (Ser727) Magnetic Bead MAPmate - Cell Signaling Single Plex or Multiplex Assay

  • merck millipore,默克密理博,46-624MAG,MILLIPLEX MAP Phospho STAT3 (Ser727) Magnetic Bead MAPmate - Cell Signaling Single Plex or Multiplex Assay

    产品名称：MILLIPLEX MAP Phospho STAT3 (Ser727) Magnetic Bead MAPmate - Cell Signaling Single Plex or Multiplex Assay
    产品型号：46-624MAG
    This MILLIPLEX MAP Phospho STAT3 (Ser727) Magnetic Bead MAPmate is a Cell Signaling single plex or multiplex assay. The analyte available for this kit is STAT3 (Ser727).

    merck millipore,默克密理博,46-624MAG,MILLIPLEX MAP Phospho STAT3 (Ser727) Magnetic Bead MAPmate - Cell Signaling Single Plex or Multiplex Assay

  • 产品介绍
  • merck millipore,默克密理博,46-624MAG,MILLIPLEX MAP Phospho STAT3 (Ser727) Magnetic Bead MAPmate - Cell Signaling Single Plex or Multiplex Assay

    重要规格表

    可用的分析物 品种反应性 主要应用 检测方法
    STAT3 (Ser727)R, H, MMplexLuminex xMAP
    描述
    产品目录编号 46-624MAG
    商名
    • MILLIPLEX
    描述 MILLIPLEX MAP Phospho STAT3 (Ser727) Magnetic Bead MAPmate - Cell Signaling Single Plex or Multiplex Assay
    背景信息 STAT3
    • A transcription factor, also known as “signal transducer and activator of transcription 3”
    • STAT3 is activated by phosphorylation of Tyrosine 705 in response to various cytokines and growth factors
    • Plays a role in cell growth and death
    • Implicated in various types of cancers
    产品信息
    检测方法 Luminex xMAP
    配置 Single Plex
    板面类型 Cell Signaling
    应用
    应用 This MILLIPLEX MAP Phospho STAT3 (Ser727) Magnetic Bead MAPmate is a Cell Signaling single plex or multiplex assay. The analyte available for this kit is STAT3 (Ser727).
    主要应用
    • Multiplexing
    应用说明 • An overnight (4°C) incubation is recommended for best results
    • This assay requires 25 µL diluted cell lysate per well
    • Please consult the buffer compatibility chart or protocol for appropriate buffer choice
    • 1 - 25 μg cell lysate/well (recommended starting concentration is 20 μg)
    生物信息
    品种反应性 RatHumanMouse
    可用的分析物
    • STAT3 (Ser727)
    Entrez基因编号
    • NM_213662.1
    • NM_003150.3
    • NM_139276.2
    Entrez基因汇总 The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
    基因符号
    • MGC16063
    • STAT3
    • APRF
    • FLJ20882
    修改
    • Phosphorylation
    UniProt编号
    • P40763
    UniProt汇总 FUNCTION: SwissProt: P40763 # Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.
    SIZE: 770 amino acids; 88068 Da
    SUBUNIT: Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with NCOA1, PELP1, SOCS7 and STATIP1. Interacts with HCV core protein. Interacts with IL23R in presence of IL23. Interacts with IL31RA.
    SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
    TISSUE SPECIFICITY: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
    PTM: Tyrosine phosphorylated in response to IL-6, IL-11, CNTF, LIF, CSF-1, EGF, PDGF, IFN-alpha and OSM. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity.
    DISEASE: "SwissProt: P40763 # Defects in STAT3 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal dominant (AD-HIES) [MIM:147060]; also known as hyper-IgE syndrome or Job syndrome. AD-HIES is a rare disorder of immunity and connective tissue characterized by immunodeficiency, chronic eczema, recurrent Staphylococcal infections, increased serum IgE, eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures."
    SIMILARITY: SwissProt: P40763 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.
    MISCELLANEOUS: Involved in the gp130-mediated signaling pathway.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Recommended storage for kit components is 2 - 8°C
    包装信息
    数量 96-well plate

    merck millipore,默克密理博,46-624MAG,MILLIPLEX MAP Phospho STAT3 (Ser727) Magnetic Bead MAPmate - Cell Signaling Single Plex or Multiplex Assay

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