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品种反应性 主要应用 宿主 格式 抗体类型 R, M IHC, WB, ICC Sh Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5447 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Tropomyosin Antibody, 5NM1 and 5NM2 产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin in PBS (liquid). 应用 应用 Detect Tropomyosin using this Anti-Tropomyosin Antibody, 5NM1 & 5NM2 validated for use in WB, IC, IH. 主要应用 - Immunohistochemistry
- Western Blotting
- Immunocytochemistry
应用说明 Western Blot: 1:100-1:500. Antibody reacts with a band at 29-30kDa.
Immunocytochemistry: 1:100-1:500
Immunohistochemistry: 1:100-1:500
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide corresponding to the 9d exon from the gamma gene of tropomyosin. 表位 5NM1 and 5NM2 宿主 Sheep 特异性 Recognizes Tropomyosin 5NM1 and 5NM2. 品种反应性 RatMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_153649.3
- NM_001043351.1
- NM_001043352.1
- NM_001043353.1
- NM_152263.2
Entrez基因汇总 This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene. 基因符号 - MGC72094
- TPM3
- TM30
- MGC3261
- TRK
- NEM1
- TM30nm
- FLJ41118
- Tropomyosin-3
- OK/SW-cl.5
- TM-5
- hscp30
- TPMsk3
- MGC14582
- hTM5
- TM3
UniProt编号 - P06753
UniProt汇总 FUNCTION: SwissProt: P06753 # Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
SIZE: 284 amino acids; 32819 Da
SUBUNIT: Heterodimer of an alpha and a beta chain. Binds to TMOD1.
DOMAIN: SwissProt: P06753 The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven- residues periodicity.
DISEASE: SwissProt: P06753 # Defects in TPM3 are a cause of nemaline myopathy type 1 (NEM1) [MIM:609284]. Nemaline myopathy (NEM) is a form of congenital myopathy characterized by abnormal thread- or rod-like structures in muscle fibers on histologic examination. The clinical phenotype is highly variable, with differing age at onset and severity. NEM1 inheritance is autosomal dominant. & A chromosomal aberration involving TPM3 is a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. A rearrangement with NTRK1 generates the TRK fusion transcript by fusing the amino end of isoform 2 of TPM3 to the 3'-end of NTRK1.
SIMILARITY: Belongs to the tropomyosin family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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