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  • merck millipore,默克密理博,AB5312,Anti-Growth Associated Protein 43 Antibody

  • merck millipore,默克密理博,AB5312,Anti-Growth Associated Protein 43 Antibody

    产品名称：Anti-Growth Associated Protein 43 Antibody
    产品型号：AB5312
    This Anti-Growth Associated Protein 43 Antibody is validated for use in IC, IH, IH(P), IP, WB for the detection of Growth Associated Protein 43.

    merck millipore,默克密理博,AB5312,Anti-Growth Associated Protein 43 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5312,Anti-Growth Associated Protein 43 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Fe, B, H, M, Mk, RWB, ICC, IHCRbSerumPolyclonal Antibody
    描述
    产品目录编号 AB5312
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Growth Associated Protein 43 Antibody
    Alternate Names
    • B-50
    • GAP-43
    • Neuromodulin
    背景信息 GAP-43, a common marker of differentiating neurons, is expressed at elevated levels by developing or regenerating neurons during axon growth. While GAP-43 is an integral membrane protein associated with the cytoplasmic surface of axonal growth cones (and synapses), it is absent from dendritic growth cones. In adult brain, GAP-43 is found in high concentration in presynaptic areas where memory formation is thought to occur, such as frontal cortex, limbic system and hippocampus. Phosphorylation of GAP-43 by PKC (at Ser41 on human, mouse, rat, and bovine GAP-43 or Ser42 on chicken and Xenopus GAP-43) is specifically correlated with certain forms of synaptic plasticity.
    产品信息
    格式 Serum
    控制
    • Rat dorsal root ganglion tissue that has been subjected to a spinal nerve ligation, cultured neurons
    演示 Serum. Liquid with 0.02% sodium azide added as a preservative.
    应用
    应用 This Anti-Growth Associated Protein 43 Antibody is validated for use in IC, IH, IH(P), IP, WB for the detection of Growth Associated Protein 43.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    • Immunohistochemistry
    应用说明 Immunocytochemistry: 1:100-1:400 for mouse primary neurons, NTera2 neurons.

    Immuohistochemistry: 1:2,000 on coronal sections of adult visual cortex (McIntosh and Parkinson, 1990). AB5312 has been used to stain GAP-43 in 4% paraformaldehyde-fixed paraffin-embedded tissue sections of mouse olfactory bulb (Legrier, 2001).

    Western blot: 1:500 - 1:1,000. Detects a single band at approximately 50 kDa on western blots of protein extracts from adult visual cortex (McIntosh and Parkinson, 1990).

    Immunoprecipitation

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Purified GAP-43 from feline brain (McIntosh and Parkinson, 1990).
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 AB5312 specifically recognizes GAP-43 regardless of the protein's phosphorylation state. This antiserum has been refered to in the literature as CG-1.
    品种反应性 FelineBovineHumanMouseMonkeyRat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002045.2
    Entrez基因汇总 The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This encoded protein is considered a crucial component of an effective regenerative response in the nervous system.
    基因符号
    • neuromodulin
    • GAP43
    • PP46
    • Neuromodulin
    • B-50
    纯化方法 Unpurified
    UniProt编号
    • P17677
    UniProt汇总 FUNCTION: SwissProt: P17677 # This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons.
    SIZE: 238 amino acids; 24803 Da
    SUBUNIT: Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence (By similarity).
    SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes.
    PTM: Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.
    SIMILARITY: SwissProt: P17677 ## Belongs to the neuromodulin family. & Contains 1 IQ domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB5312,Anti-Growth Associated Protein 43 Antibody

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