merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5060,Anti-Substance P Receptor Antibody, pain

  • merck millipore,默克密理博,AB5060,Anti-Substance P Receptor Antibody, pain

    产品名称：Anti-Substance P Receptor Antibody, pain
    产品型号：AB5060
    Anti-Substance P Receptor Antibody, pain detects level of Substance P Receptor & has been published & validated for use in IF, IH & WB.

    merck millipore,默克密理博,AB5060,Anti-Substance P Receptor Antibody, pain

  • 产品介绍
  • merck millipore,默克密理博,AB5060,Anti-Substance P Receptor Antibody, pain

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, Gp, MWB, IHCRbSerumPolyclonal Antibody
    描述
    产品目录编号 AB5060
    Replaces AB5800
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Substance P Receptor Antibody, pain
    Alternate Names
    • NK-1 Receptor
    背景信息 Substance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapses. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs.
    产品信息
    格式 Serum
    控制
    • Spinal Cord, brain membrane lysate
    演示 Rabbit polyclonal serum in buffer containing liquid with no preservatives.
    应用
    应用 Anti-Substance P Receptor Antibody, pain detects level of Substance P Receptor & has been published & validated for use in IF, IH & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Immunohistochemistry:
    A previous lot was used at 1:100-1:1,000 dilution.

    Western Blot Analysis:
    A previous lot was used at 1:500 dilution.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide that corresponds to a 23 amino acid sequence (385-407) of the COOH terminus of the rat Substance P Receptor (NK-1).
    表位 C terminus
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Specific for the Substance P Receptor (NK-1).
    品种反应性 RatGuinea PigMouse
    Species Reactivity Note Rat, mouse and guinea pig.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_003182.1
    Entrez基因汇总 This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene.
    基因符号
    • TAC2
    • TAC1
    • NK2
    • NKA
    • NKNA
    • Hs.2563
    • PPT
    纯化方法 Unpurified
    UniProt编号
    • P20366
    UniProt汇总 FUNCTION: SwissProt: P20366 # Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
    SIZE: 129 amino acids; 15003 Da
    SUBCELLULAR LOCATION: Secreted.
    SIMILARITY: SwissProt: P20366 ## Belongs to the tachykinin family.
    产品使用声明
    质量保证 Evaluated by western blot on Mouse brain membrane lysates.

    Western Blot Analysis:
    1:500 dilution of this antibody detected NK-1R on 10 μg of Mouse brain membrane lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20ºC from date of receipt.
    包装信息
    数量 50 µL

    merck millipore,默克密理博,AB5060,Anti-Substance P Receptor Antibody, pain

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