- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB2292 描述 Anti-phospho GluR1 (Thr840) Antibody Alternate Names - glutamate receptor, ionotropic, AMPA 1
- AMPA 1
- AMPA-selective glutamate receptor 1
- Glutamate receptor ionotropic, AMPA 1
背景信息 Glutamate receptors (GluRs) can be categorized as ionotropic or metabotropic and subcatergorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contribute to the functional diversity of AMPA receptors. In general, AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. GluR1 is believed to mediate calcium influx, and has a vital function in synaptic plasticity related to learning. Reduction in GluR1 has been caused by FMR1 gene mutation and contributes to fragile X syndrome. Changes in expression of GluR1 receptors on dopamine neurons have been correlated with sensitization of drugs of abuse. 产品信息 格式 Affinity Purified 控制 - Phosphatase treated and untreated rat hippocampal P2 tissue lysates
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Detect phospho GluR1 (Thr840) using this Anti-phospho GluR1 (Thr840) Antibody validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Linear peptide corresponding to rat GluR1 phosphorylated at Thr840. 表位 Phosphorylated Thr840 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes GluR1 when phosphorylated at Thr840. 品种反应性 Rat Species Reactivity Note Demonstrated to react with rat. Predicted to react with human and mouse based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_113796
Entrez基因汇总 Mouse homolog may play a role in regulation of neuronal synaptic plasticity and conditioned reinforcement learning. [RGD] 基因符号 - GRIA1
- GLUH1
- GLUR1
- GLURA
- GluR-1
- GluR-A
- GluR-K1
- HBGR1
修改 - Phosphorylation
纯化方法 Affinity purified UniProt编号 - P19490
UniProt汇总 FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
SUBUNIT STRUCTURE: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with DLG1 via its C-terminus. Interacts with CACNG2, HIP1 and probably RASGRF2.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Note: Interaction with CACNG2 promotes cell surface expression.
TISSUE SPECIFICITY: Detected in cerebellum (at protein level).
PTM: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis By similarity.
POLYMORPHISM: Both variants Ser-710 and Thr-710 are phosphorylated at this position.
MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.
SEQUENCE SIMILARITIES: Belongs to the glutamate-gated ion channel (TC 1.A.10) family. [View classification]产品使用声明 质量保证 Evaluated by Western Blot in phosphatase treated and untreated rat hippocampus P2 tissue lysates.
Western Blot Analysis: 1 µg/mL of this antibody detected GluR1 on 10 µg of phosphatase untreated rat hippocampus P2 tissue lysates while showing no reactivity on a phosphatase treated control.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,454586,NMDAR2C/2D Inhibitor, DQP-1105 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,SF-704,EZH2; Human, Cyanine 5, RNA Detection Probe,SmartFlare
相关产品
merck millipore,默克密理博,AP503H,Goat Anti-Chicken IgG (H+L) Antibody, PE conjugate
merck millipore,默克密理博,FC010-5MG,Human Plasma Fibronectin Purified Protein
merck millipore,默克密理博,05-338,Anti-Fas Antibody (human, neutralizing), clone ZB4
merck millipore,默克密理博,GF430,HumanKine IL-6, Human Recombinant Xeno-Free
merck millipore,默克密理博,454586,NMDAR2C/2D Inhibitor, DQP-1105 - Calbiochem
merck millipore,默克密理博,SF-704,EZH2; Human, Cyanine 5, RNA Detection Probe,SmartFlare
merck millipore,默克密理博,AB5060,Anti-Substance P Receptor Antibody, pain
merck millipore,默克密理博,14-676,NLK Protein, active, 10 µg
merck millipore,默克密理博,420107,Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem