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品种反应性 主要应用 宿主 格式 抗体类型 M, H IP Rb Purified Polyclonal Antibody 描述 产品目录编号 AB4070 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-DAP12 Antibody 背景信息 DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells (Bakker, 2000, Campbell, 1999). DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction (McVicar, 1998). Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice (Bakker. 2000, Tomasello, 2000), as well as presenile dementia and bone cysts in humans (Paloneva, 2000). 产品信息 格式 Purified 控制 - POSITIVE CONTROL: NKp44 positive cells.
演示 Purified immunoglobulin. Liquid in phosphate buffered saline with 0.08% sodium azide. 应用 应用 Anti-DAP12 Antibody detects level of DAP12 & has been published & validated for use in IP. 主要应用 - Immunoprecipitation
应用说明 Immunoprecipitation (2-4 μg/mg of protein lysate)
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Recombinant DAP12 protein. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes DAP12 protein. 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_198125.1
- NM_003332.2
Entrez基因汇总 This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Two alternative transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described, but their full-length nature has not been deterimined. 基因符号 - PLOSL
- TYROBP
- DAP12
- PLO-SL
- KARAP
UniProt编号 - O43914
UniProt汇总 FUNCTION: SwissProt: O43914 # Non-covalently associates with membrane glycoproteins of the killer-cell inhibitory receptor (KIR) family without an ITIM in their cytoplasmic domain. Cross-linking of KIR-TYROBP complexes results in cellular activation.
SIZE: 113 amino acids; 12179 Da
SUBUNIT: Homodimer; disulfide-linked. Interacts with SIRPB1 and TREM1. Interacts with CLECSF5. Interacts with SIGLEC14.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum.
PTM: Tyrosine phosphorylated.
DISEASE: "SwissProt: O43914 # Defects in TYROBP are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) [MIM:221770]; also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns."
SIMILARITY: SwissProt: O43914 ## Belongs to the TYROBP family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,676604,PhosphoDetect™ Anti-VASP (pSer¹⁵⁷) Mouse mAb (5C6)
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