merck millipore,默克密理愽
  • merck millipore,默克密理博,06-629,Anti-Estrogen Receptor β Antibody

  • merck millipore,默克密理博,06-629,Anti-Estrogen Receptor β Antibody

    产品名称：Anti-Estrogen Receptor β Antibody
    产品型号：06-629
    Detect Estrogen Receptor β also known as Estrogen receptor beta with Anti-Estrogen Receptor β Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in IHC & WB.

    merck millipore,默克密理博,06-629,Anti-Estrogen Receptor β Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-629,Anti-Estrogen Receptor β Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Pm, H, RWB, IHCRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 06-629
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Estrogen Receptor β Antibody
    背景信息 Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ERα and ERβ, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ERα and ERβ have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ERα and ERβ may be regulated by distinct mechanisms even though they share many functional characteristics.
    产品信息
    格式 Purified
    控制
    • Normal human breast cancer tissue (IHC), MCF-7 cells, NIH/3T3 whole cell lysate
    演示 UnPurified mouse ascites containing no preservatives.
    应用
    应用 Detect Estrogen Receptor β also known as Estrogen receptor beta with Anti-Estrogen Receptor β Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in IHC & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    生物信息
    免疫原品种 peptide (YAEPQKSPWCEARSLEHT) representing amino acids 54-71 of rat and mouse estrogen receptor β and amino acids 46-63 of human estrogen receptor β
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes the 53kDa ERβ splice variant in cell lysates. Non-specific doublet detected at 75-77kDa and an additional band at 47kDa, likely an ERβ degradation product. Also recognizes Recognizes recombinant ERβ, long form, at 59kDa. Does not detect ERα.
    同种型 IgG
    品种反应性 PrimateHumanRat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_001437
    Entrez基因汇总 This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.
    基因符号
    • ER-beta
    • ESR2
    • ESR-BETA
    • ESTRB
    • ESRB
    • ER-BETA
    • NR3A2
    • Erb
    纯化方法 Protein A purfied
    UniProt编号
    • Q92731
    UniProt汇总 FUNCTION: SwissProt: Q92731 # Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
    SIZE: 530 amino acids; 59216 Da
    SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with PELP1 and UBE1C. Isoform beta-2/cx preferentially forms a hetereodimer with ESR1 rather than ESR2 and inhibits DNA-binding by ESR1. Interacts with AKAP13.
    SUBCELLULAR LOCATION: Nucleus.
    TISSUE SPECIFICITY: Isoform beta-1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform beta-2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform beta-3 is found in testis. Isoform beta-4 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform beta-5 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain.DOMAIN:SwissProt: Q92731 Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
    SIMILARITY: Belongs to the nuclear hormone receptor family. NR3 subfamily. & Contains 1 nuclear receptor DNA-binding domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates from MCF-7 cell lysate
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,06-629,Anti-Estrogen Receptor β Antibody

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