merck millipore,默克密理博,234200,Combretastatin A-4 - CAS 117048-59-6

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

merck millipore,默克密理博,234200,Combretastatin A-4 - CAS 117048-59-6 - Calbiochem

经验配方	CAS号
C₁₈H₂₀O₅	117048-59-6

描述
概述	A synthetic Combretum caffrum-derived cell-permeable stilbenoid phenol that competes with colchicine (Cat No. 234115) tubulin binding (by 96.4% at equal molar concentration; Ki = 1.1 µM) and interferes with tubulin polymerization (IC₅₀ = 2-3 µM) as well as cellular microtubule assembly. In addition to its antimitotic and in vitro cancer growth inhibition activity (IC₅₀ = 7 nM in L1210 cultures), CA4 also acts as an antivascular agent and effectively induces tumor cell necrosis in vivo by targeting endothelial cytoskeleton.
产品目录编号	234200
品牌系列	Calbiochem®
同义词	NSC 817373, 2-Methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-phenol, CA-4, Combretastatin A4, CA4, Tubulin Polymerization Inhibitor XVIII

参考
参考	Tron, G.C., et al. 2006. J. Med. Chem. 49, 3033. Griggs, J., et al. 2001. Lancet Oncol. 2, 82. Pettit, G.R., et al. 1989. Experientia 45, 209. Lin, C.M., et al. 1988. Mol. Pharmacol. 34, 200.

生物信息
纯度	≥97% by HPLC

理化信息
溶解度	DMSO or EtOH

安全信息
S相	S: 22-24/25-36 Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing.

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,234200,Combretastatin A-4 - CAS 117048-59-6 - Calbiochem

whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech