merck millipore,默克密理愽
  • merck millipore,默克密理博,MABT203,Anti-Abl (c-, v-, Bcr-) Antibody, clone 24-21

  • merck millipore,默克密理博,MABT203,Anti-Abl (c-, v-, Bcr-) Antibody, clone 24-21

    产品名称：Anti-Abl (c-, v-, Bcr-) Antibody, clone 24-21
    产品型号：MABT203
    Anti-Abl (c-, v-, Bcr-) Antibody, clone 24-21 detects level of Abl (c-, v-, Bcr-), clone 24-21 & has been published & validated for use in Western Blotting, ICC.

    merck millipore,默克密理博,MABT203,Anti-Abl (c-, v-, Bcr-) Antibody, clone 24-21

  • 产品介绍
  • merck millipore,默克密理博,MABT203,Anti-Abl (c-, v-, Bcr-) Antibody, clone 24-21

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABT203
    描述 Anti-Abl (c-, v-, Bcr-) Antibody, clone 24-21
    Alternate Names
    • p150
    • Tyrosine-protein kinase ABL1
    • Abelson murine leukemia viral oncogene homolog 1
    • Abelson tyrosine-protein kinase 1
    • Proto-oncogene c-Abl
    背景信息 c-Abl, v-Abl, and Bcr-abl are ubiquitously expressed non-receptor tyrosine kinases that are involved in a plethora of cellular processes. c-Abl is involved in cytoskeleton remodeling and facilitates cell adhesion and cell motility. c-Abl achieves cytoskeleton remodeling by phosphorylating and activating a wide variety of cytoskeleton-associated proteins such as WASF3, ANXA1, DBN1, DBNL, CTTN, RAPH1, ENAH, MAPT, and PXN. Abl-1 also phosphorylates a number of receptor tyrosine kinases and is involved in regulating levels of EGFR by endocytosis. c-Abl may also play a role in DNA damage response via the ATM pathway, among other cellular processes. Whereas v-Abl is known to be involved in pre-B cell transformation in mice, Bcr-Abl is reported to promote cellular growth in leukemia cells and maintain CML phenotype. Many v-Abl- and Bcr-abl-mediated signaling events have been described; however the complexity and function of these pathways require further elucidation.
    产品信息
    格式 Purified
    控制
    • K562 cell lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Abl (c-, v-, Bcr-) Antibody, clone 24-21 detects level of Abl (c-, v-, Bcr-), clone 24-21 & has been published & validated for use in Western Blotting, ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Abl (c-, v-, Bcr-) in COS-7 and 7C411 cells (Goga, A., et al. (1993). Mol Cell Biol. 13(8):4967-49775.).
    生物信息
    免疫原品种 Recombinant protein corresponding to the carboxyl region of human v-Abl fused with TrpE.
    表位 C-terminus
    克隆 24-21
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes the c-terminus of c-Abl, v-Abl, and Bcr-Abl.
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_005148
    基因符号
    • JTK7
    • ABL1
    • ABL
    纯化方法 Protein G purified
    UniProt编号
    • P00519
    产品使用声明
    质量保证 Evaluated by Western Blot in K562 cell lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected Abl (c-, v-, Bcr-) in 10 µg of K562 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABT203,Anti-Abl (c-, v-, Bcr-) Antibody, clone 24-21

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