- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,MAB5542,Anti-Prion Protein Antibody, clone 2G11
产品名称：Anti-Prion Protein Antibody, clone 2G11
产品型号：MAB5542
Detect Prion Protein using this Anti-Prion Protein Antibody, clone 2G11 validated for use in IH(P) & WB.
merck millipore,默克密理博,MAB5542,Anti-Prion Protein Antibody, clone 2G11
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, R, H, Sh WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB5542 描述 Anti-Prion Protein Antibody, clone 2G11 Alternate Names - prion-related protein
- CD230 antigen
- major prion protein
- prion protein
- prion protein (p27-30)
- prion protein PrP
背景信息 The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. 产品信息 格式 Purified 控制 - Rat brain tissue lysate.
演示 Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3. 应用 应用 Detect Prion Protein using this Anti-Prion Protein Antibody, clone 2G11 validated for use in IH(P) & WB. 主要应用 - Western Blotting
应用说明 Immunohistochemistry:
1:50-1:300 working dilutions of anti-Prion Protein, clone 2G11 localizes prion protein in rat brain paraffin embedded tissue.生物信息 免疫原品种 KLH conjugated synthetic linear peptide corresponding to the C-terminus. 表位 C-terminus 克隆 2G11 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Cat. # MAB5542 recognizes the C-terminus of Prion Protein. 同种型 IgG2aκ 品种反应性 MouseRatHumanSheep Species Reactivity Note Rat. May react with Mouse, Sheep (See References) and Human based on sequence homology. Reactivity with other species has not been determined. 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000311.3
Entrez基因汇总 The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq]
基因符号 - prion
- ASCR
- CD230
- CJD
- GSS
- MGC26679
- OTTHUMP00000030162
- OTTHUMP00000030163
- PRIP
- PRP
- PrP
- PrP27-30
- PrP33-35C
- PrPc
- p27-30
纯化方法 Protein G purfied UniProt编号 - P23907
UniProt汇总 FUNCTION: The function of PrP is not known. PrP is encoded in the host genome and is expressed both in normal and infected cells.
SUBUNIT STRUCTURE: PrP has a tendency to aggregate yielding polymers called "rods". Component of a epididymal complex at least composed of soluble form of prion protein PRNP, CLU, BPI, EST7, MANBA and GLB1. Interacts with GRB2, PRNPIP and SYN1 By similarity.
SUBCELLULAR LOCATION:Cell membrane; Lipid-anchor › GPI-anchor. Golgi apparatusBy similarity.
DISEASE: Polymorphism at position 171 may be related to the alleles of scrapie incubation-control (SIC) gene in this species.
Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
Scrapie is a transmissible neurodegenerative disorder of sheep and goats. Most sheep that contract the disease naturally die between 24 and 50 months of age. The incubation period in sheep depends on the strain(s) of the infecting pathogen, sheep age at exposure, and the sheep genotype. The survival time is mainly determined by a single genetic locus, SIP, which has two alleles, susceptible (sa) and resistant (pa). Short incubation period is conferred by the partially dominant sa allele. Scrapie can be spread between flockmates, or it can be transmitted from an infected ewe to its lamb.
SIMILARITY: Belongs to the prion family.
产品使用声明 质量保证 Western Blot:
A 1 mg/mL dilution of this antibody was used to detect anti-Prion Protein, clone 2G11使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8ºC from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,71743,D-Tube™ Dialyzer Mega, 15 ml, MWCO 6-8 kDa
下一件merck millipore产品：merck millipore,默克密理博,MABT203,Anti-Abl (c-, v-, Bcr-) Antibody, clone 24-21
相关产品
merck millipore,默克密理博,107687,蔗糖
merck millipore,默克密理博,MAB4427,TG30 Antibody, clone TG30
merck millipore,默克密理博,AB4070,Anti-DAP12 Antibody
merck millipore,默克密理博,676604,PhosphoDetect™ Anti-VASP (pSer¹⁵⁷) Mouse mAb (5C6)
merck millipore,默克密理博,71743,D-Tube™ Dialyzer Mega, 15 ml, MWCO 6-8 kDa
merck millipore,默克密理博,MABT203,Anti-Abl (c-, v-, Bcr-) Antibody, clone 24-21
merck millipore,默克密理博,ABE1044,Anti-HSF 1 Antibody
merck millipore,默克密理博,124540,二氢酰胺腺碱二核甘磷酸四钠
