merck millipore,默克密理愽
  • merck millipore,默克密理博,AB3841,Anti-Connexin 43 Antibody, phospho-specific (Ser368)

  • merck millipore,默克密理博,AB3841,Anti-Connexin 43 Antibody, phospho-specific (Ser368)

    产品名称：Anti-Connexin 43 Antibody, phospho-specific (Ser368)
    产品型号：AB3841
    This Anti-Connexin 43 Antibody, phospho-specific (Ser368) is validated for use in WB for the detection of Connexin 43.

    merck millipore,默克密理博,AB3841,Anti-Connexin 43 Antibody, phospho-specific (Ser368)

  • 产品介绍
  • merck millipore,默克密理博,AB3841,Anti-Connexin 43 Antibody, phospho-specific (Ser368)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, Ht, M, MkWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB3841
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Connexin 43 Antibody, phospho-specific (Ser368)
    产品信息
    格式 Affinity Purified
    演示 Protein A and peptide affinity purified immunoglobulin. Liquid in 10 mM sodium HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, with 50% glycerol.
    应用
    应用 This Anti-Connexin 43 Antibody, phospho-specific (Ser368) is validated for use in WB for the detection of Connexin 43.
    主要应用
    • Western Blotting
    应用说明 Western blotting 1:1,000 (for best results, incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight)

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 KLH-conjugated, synthetic phospho-peptide corresponding to residues surrounding Ser368 of human Connexin 43.
    表位 phospho-specific (Ser368)
    宿主 Rabbit
    特异性 Recognizes Ser368 phosphorylated Connexin 43. Connexin 43 (Cx43) is a member of the large family of gap junction proteins. Connexins assemble as a hexamer and are transported to the plasma membrane to create a hemichannel that can associate with hemichannels on nearby cells to create cell-to-cell channels. Clusters of these channels assemble to make gap junctions. Gap-junction communication is important in development and regulation of cell growth.
    品种反应性 RatHumanHamsterMouseMonkey
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000165.3
    Entrez基因汇总 This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations.
    基因符号
    • Connexin-43
    • GJA1
    • GJAL
    • Cx43
    • DFNB38
    • SDTY3
    • CX43
    • ODD
    • ODDD
    • ODOD
    修改
    • Phosphorylation
    UniProt编号
    • P17302
    UniProt汇总 FUNCTION: SwissProt: P17302 # One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.
    SIZE: 382 amino acids; 43008 Da
    SUBUNIT: A connexon is composed of a hexamer of connexins. Interacts with SGSM3.
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
    TISSUE SPECIFICITY: Expressed in the heart and fetal cochlea.
    DISEASE: SwissProt: P17302 # Defects in GJA1 are the cause of autosomal dominant oculodentodigital dysplasia (ODDD) [MIM:164200]; also known as oculodentoosseous dysplasia. ODDD is a highly penetrant syndrome presenting with craniofacial (ocular, nasal, dental) and limb dysmorphisms, spastic paraplegia, and neurodegeneration. Craniofacial anomalies tipically include a thin nose with hypoplastic alae nasi, small anteverted nares, prominent columnella, and microcephaly. Brittle nails and hair abnormalities of hypotrichosis and slow growth are present. Ocular defects include microphthalmia, microcornea, cataracts, glaucoma, and optic atrophy. Syndactyly type III and conductive deafness can occur in some cases. Cardiac abnormalities are observed in rare instances. & Defects in GJA1 may be the cause of syndactyly type III (SDTY3) [MIM:186100]. Syndactyly is an autosomal dominant trait and is the most common congenital anomaly of the hand or foot. It is marked by persistence of the webbing between adjacent digits, so they are more or less completely attached. In this type there is usually complete and bilateral syndactyly between the fourth and fifth fingers. Usually it is soft tissue syndactyly but occasionally the distal phalanges are fused. The fifth finger is short with absent or rudimentary middle phalanx. The feet are not affected. & Defects in GJA1 a the cause of hypoplastic left heart syndrome (HLHS) [MIM:241550]. HLHS refers to the abnormal development of the left-sided cardiac structures, resulting in obstruction to blood flow from the left ventricular outflow tract. In addition, the syndrome includes underdevelopment of the left ventricle, aorta, and aortic arch, as well as mitral atresia or stenosis.
    SIMILARITY: SwissProt: P17302 ## Belongs to the connexin family. Alpha-type (group II) subfamily.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20ºC for 12 months after date of receipt. Do not aliquot.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB3841,Anti-Connexin 43 Antibody, phospho-specific (Ser368)

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