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merck millipore,默克密理博,373210,HDL Receptor SR-BI Inhibitor, BLT-1 - CAS 321673-30-7 - Calbiochem
产品名称：HDL Receptor SR-BI Inhibitor, BLT-1 - CAS 321673-30-7 - Calbiochem
产品型号：373210
The HDL Receptor SR-BI Inhibitor, BLT-1, also referenced under CAS 321673-30-7, controls the biological activity of HDL Receptor SR-B. This small molecule/inhibitor is primarily used for Phosphorylati More>>
merck millipore,默克密理博,373210,HDL Receptor SR-BI Inhibitor, BLT-1 - CAS 321673-30-7 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₂H₂₃N₃S 321673-30-7 描述 概述 A cell-permeable thiosemicarbazone copper chelator that potently blocks the HDL receptor SR-BI- (scavenger receptor, class B, type I) mediated lipid uptake (IC50 = 21 and 57 nM against DiI and CE uptake, respectively, from DiI-HDL and CE-HDL using hamster ldlA-7 cells expressing murine SR-BI) in a reversible manner, while exerting little effect toward intracellular membrane trafficking or cytoskeletal organization. BLT-1 chelates Cu+2 in a 2:1 stoichiometric ratio and a half molar equivalent of CuCl2 is shown to fully prevent zebrafish embryos from BLT-1-induced development defects, while BLT-1 can likewise be used to chelate excess amount of copper (>4 µM) and rescue embryos from copper toxicity. 产品目录编号 373210 品牌系列 Calbiochem®
同义词 Block Lipid Transport-1, 2-Hexyl-1-cyclopentanone thiosemicarbazone, 33M20 参考 参考 Nieland, T.J.F., et al. 2008. Biochemistry 47, 460.
Raldua, D., and Babin, P.J. 2007. Toxicol. Lett. 175, 1.
Nieland, T.J.F., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 15422.
Peterson, R.T., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 12965.产品信息 CAS号 321673-30-7 形式 White solid Hill配方 C₁₂H₂₃N₃S 化学配方 C₁₂H₂₃N₃S Molar Mass 241.4 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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