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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ELISA Ch Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB3421 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Complement C3 Antibody 产品信息 格式 Affinity Purified 演示 Chicken IgY fraction, in 0.15 M NaCl, 0.02 M NaH2PO4, 0.1% NaN3, pH 7.2. 应用 应用 Detect Complement C3 using this Anti-Complement C3 Antibody validated for use in ELISA. 主要应用 - ELISA
应用说明 ELISA, direct: 0.1 μg/mL
It is expected that the antibody will also work for Western blot, immunohistochemistry and immunocytochemistry. Specific reactivity has not been confirmed.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Human C3, full length plasma protein. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Chicken 特异性 Complement C3 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000064.2
Entrez基因汇总 Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptable to bacteria infection. 基因符号 - CPAMD1
- C3
- ASP
- ARMD9
UniProt编号 - P01024
UniProt汇总 FUNCTION: SwissProt: P01024 # Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
SIZE: 1663 amino acids; 187148 Da
SUBUNIT: C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain). During pregnancy, C3dg exists as a complex (probably a 2:2:2 heterohexamer) with AGT and the proform of PRG2. Interacts with CR2 and VSIG4.
SUBCELLULAR LOCATION: Secreted.
PTM: C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. Other proteases produce other fragments such as C3d or C3g.
DISEASE: SwissProt: P01024 # Defects in C3 are the cause of C3 deficiency [MIM:120700]. It can result in susceptibility to pyogenic infection. & Genetic variation in C3 is associated with susceptibility to age-related macular degeneration type 9 (ARMD9) [MIM:611378]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
SIMILARITY: SwissProt: P01024 ## Contains 1 anaphylatoxin-like domain. & Contains 1 NTR domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8*C in undiluted aliquots up to 6 months after date of receipt.
Avoid freezing temperatures.包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,AB1555P,Anti-NMDAR2A Antibody
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