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merck millipore,默克密理博,04-1583,Anti-Interleukin 21 (IL-21) Antibody, clone 1G8
产品名称：Anti-Interleukin 21 (IL-21) Antibody, clone 1G8
产品型号：04-1583
This Anti-Interleukin 21 (IL-21) Antibody, clone 1G8 is validated for use in WB, ELISA for the detection of Interleukin 21 (IL-21).
merck millipore,默克密理博,04-1583,Anti-Interleukin 21 (IL-21) Antibody, clone 1G8
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ELISA, WB M Purified Monoclonal Antibody 描述 产品目录编号 04-1583 描述 Anti-Interleukin 21 (IL-21) Antibody, clone 1G8 Alternate Names - interleukin 2
- interleukin-2
- interleukin-21 isoform
背景信息 Interleukin 21 (IL-21) is a cytokine that has immunoregulatory activity on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. IL-21 induces cell division/proliferation in its target cells and is expressed in activated human CD4+ T cells. IL-21 may promote the transition between innate and adaptive immunity and may play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. IL-21 expression is up-regulated in Th2 and Th17 subsets of T helper cells, as well as follicular T cells. Furthermore IL-21 is expressed in NK T cells regulating the function of these cells. IL-21 is also produced by Hodgkin's lymphoma (HL) cancer cells and may explain a great deal of the behavior of classical Hodgkin's lymphoma including clusters of other immune cells gathered around HL cells in cultures. 产品信息 格式 Purified 控制 - Human IL-21 recombinant protein
演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-Interleukin 21 (IL-21) Antibody, clone 1G8 is validated for use in WB, ELISA for the detection of Interleukin 21 (IL-21). 主要应用 - ELISA
- Western Blotting
应用说明 ELISA Analysis: A previous lot was used by an independent laboratory in ELISA. (Dr. Gerard Zurawski, Baylor Institute for Immunology Research, Dallas, TX) 生物信息 免疫原品种 Full length recombinant protein corresponding to human IL-21. 克隆 AB43.50.32H5.1G8 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2aκ 品种反应性 Human Species Reactivity Note Demonstrated to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_068575
基因符号 - IL21
- Za11
- IL-21
纯化方法 Protein G UniProt编号 - Q9HBE4
UniProt汇总 FUNCTION: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells By similarity. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
SUBCELLULAR LOCATION: Secreted
TISSUE SPECIFICITY: Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.
SEQUENCE SIMLARITIES: Belongs to the IL-15/IL-21 family.
SEQUENCE CAUTION: The sequence AAG29348.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH66258.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH66259.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH66260.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH66261.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH66262.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH69124.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAU88182.1 differs from that shown. Reason: Erroneous initiation.
The sequence ABG36529.1 differs from that shown. Reason: Erroneous initiation.产品使用声明 质量保证 Evaluated by Western Blot from human IL-21 recombinant protein.
Western Blot Analysis: 0.5 µg/mL of this antibody detected IL-21 on 10 µg of human IL-21 recombinant protein.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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