merck millipore,默克密理博,AB1555P,Anti-NMDAR2A Antibody

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merck millipore,默克密理博,AB1555P,Anti-NMDAR2A Antibody
产品名称：Anti-NMDAR2A Antibody
产品型号：AB1555P
Anti-NMDAR2A Antibody is an antibody against NMDAR2A for use in IH, IP & WB.

merck millipore,默克密理博,AB1555P,Anti-NMDAR2A Antibody

产品介绍

merck millipore,默克密理博,AB1555P,Anti-NMDAR2A Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
F, H, M, R	WB, IHC	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	AB1555P
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-NMDAR2A Antibody
Alternate Names	glutamate receptor, ionotropic, N-methyl D-aspartate 2A N-methyl D-aspartate receptor subtype 2A N-methyl-D-aspartate receptor subunit 2A NMDA receptor subtype 2A glutamate receptor ionotropic
背景信息	NMDA (N-methyl-D-aspartate) receptors are a class of ionotropic glutamate receptors. The NMDAR channel has been shown to be involved in long term potentiation, an activity dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).

产品信息
格式	Affinity Purified
控制	NMDAR2A is present in high concentrations in the hippocampus.
演示	Purified rabbit polyclonal lyophilized from ammonium bicarbonate (5 mM) so some residual salt may also be present. Reconstitute with 50 μL of PBS. Contains no preservative.

应用
应用	Anti-NMDAR2A Antibody is an antibody against NMDAR2A for use in IH, IP & WB.
主要应用	Western Blotting Immunohistochemistry
应用说明	Immunoprecipitation: 3 μg of a previous lot was used to (under appropriate conditions) quantitatively immunoprecipitate all NMDAR2A in 200 μg of rat brain. Immunohistochemistry: A previous lot of this antibody was used at 1:1,000-1:2,000 dilution. Optimal working dilutions must be determined by the end user.

生物信息
免疫原品种	C-Terminal Fusion Protein of rat NMDAR2A, aa 1253-1391.
表位	C-terminus
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	NMDAR2A. By Western blot it recognizes a 180 kDa band in rat brain membranes. Does not react with NMDAR2B or NMDAR2C. Immunolabeling is blocked by preadsorption of antibody with the immunogen.
品种反应性	FishHumanMouseRat
Species Reactivity Note	Human, rat, mouse, and fish.
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_000824
Entrez基因汇总	N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
基因符号	NR2A GRIN2A hNR2A Glutamate NMDAR2A
纯化方法	Immunoaffinity purified
UniProt编号	Q12879
UniProt汇总	Function: NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits. Subunit structure: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of AIP1, INADL and DLG4 By similarity. Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Sequence similarities: Belongs to the glutamate-gated ion channel (TC 1.A.10) family. [View classification]

产品使用声明
质量保证	Routinely evaluated by Western Blot on Rat Brain Microsomal lysates. Western Blot Analysis: 1:500 dilution of this lot detected NMDAR2A on 10 μg of Rat Brain Microsomal lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Lyophilized material stable for 1 year at -20°C from date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up 6 months. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

储存和货运信息

存储条件

Lyophilized material stable for 1 year at -20°C from date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up 6 months.

Handling Recommendations:
Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.