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  • merck millipore,默克密理博,AB3073,Anti-Aquaporin 6 Antibody, kidney specific form

  • merck millipore,默克密理博,AB3073,Anti-Aquaporin 6 Antibody, kidney specific form

    产品名称：Anti-Aquaporin 6 Antibody, kidney specific form
    产品型号：AB3073
    Anti-Aquaporin 6 Antibody, kidney specific form is an antibody against Aquaporin 6 for use in ELISA & WB.

    merck millipore,默克密理博,AB3073,Anti-Aquaporin 6 Antibody, kidney specific form

  • 产品介绍
  • merck millipore,默克密理博,AB3073,Anti-Aquaporin 6 Antibody, kidney specific form

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, ELISARbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB3073
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Aquaporin 6 Antibody, kidney specific form
    Alternate Names
    • AQP2L
    • AQP6
    背景信息 Water is a critical component of all living cells. Interestingly, tissue membranes show a great degree of water permeability. Mammalian red cells, renal proximal tubules, and descending thin limb of Henle are extraordinarily permeable to water. Water crosses hydrophobic plasma membranes either by simple diffusion or through a facilitative transport mechanism mediated by special protein "aquaporin". Over the last decade, genes for several members of aquaporin family have been cloned, expressed, and their distribution studied in many tissues. Aquaporin-0 or MIP26 (major intrinsic protein 26 kDa), and Aquaporin-1 (purified from red cells) also called CHIP-28 (channel forming integral protein, 28 kDa; 268 AA; gene locus 7p14) has been the foundation of the growing family of aquaporins. The lens specific Aquaporin-0 represents up to 80% of total lens membrane protein. Defects in MIP26 are a cause of autosomal dominant cataract. The cataract Fraser mutation (CAT-FR or Shriveled) is a transposon-induced splicing error that substitutes a long terminal repeat sequence for the c-terminus of MIP. The lens opacity mutation (LOP) is an AA substitution that inhibits targeting of MIP to the cell membrane. Aquaporin-6 (WCH3 or hKID or AQP2-like; 282 aa; 29 kDa; chromosome 12q13) is found only in the kidney with low water permeability. Aquaporin families of proteins are predicted to contain six transmembrane domains. The N and C-terminus are predicted to be cytoplasmic. Aquaporin-6 shows greatest homology with hMIP (48%) and hAQP-2 (52%). It also has similarity with human MIWC (AQP4; 34%), CHIP-28 (AQP1; 38%), and GLIP (AQP3; 22%).
    产品信息
    格式 Affinity Purified
    演示 Affinity Purified immunoglobulin in PBS containing 0.1% BSA as stabilizer and 0.05% sodium azide as a preservative.
    应用
    应用 Anti-Aquaporin 6 Antibody, kidney specific form is an antibody against Aquaporin 6 for use in ELISA & WB.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Western blot: 1-10 μg/mL using Chemiluminescence technique Immunohistochemistry: We recommend using the affinity purified antibody at 2-10 μg/mL in paraformaldehyde fixed sections of tissues.

    ELISA: 0.5-1.0 μg/mL

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 A 19 AA synthetic peptide within the carboxy terminal domain of human AQP6 (Ma et al. 1996) was selected for antibody production. This domain is predicted to be cytoplasmic.
    表位 kidney specific form
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Water is a critical component of all living cells. Interestingly, tissue membranes show a great degree of water permeability. Mammalian red cells, renal proximal tubules, and descending thin limb of Henle are extraordinarily permeable to water. Water crosses hydrophobic plasma membranes either by simple diffusion or through a facilitative transport mechanism mediated by special protein "aquaporin". Over the last decade, genes for several members of aquaporin family have been cloned, expressed, and their distribution studied in many tissues. Aquaporin-0 or MIP26 (major intrinsic protein 26 kDa), and Aquaporin-1 (purified from red cells) also called CHIP-28 (channel forming integral protein, 28 kDa; 268 AA; gene locus 7p14) has been the foundation of the growing family of aquaporins. The lens specific Aquaporin-0 represents up to 80% of total lens membrane protein. Defects in MIP26 are a cause of autosomal dominant cataract. The cataract Fraser mutation (CAT-FR or Shriveled) is a transposon-induced splicing error that substitutes a long terminal repeat sequence for the c-terminus of MIP. The lens opacity mutation (LOP) is an AA substitution that inhibits targeting of MIP to the cell membrane. Aquaporin-6 (WCH3 or hKID or AQP2-like; 282 aa; 29 kDa; chromosome 12q13) is found only in the kidney with low water permeability. Aquaporin families of proteins are predicted to contain six transmembrane domains. The N and C-terminus are predicted to be cytoplasmic. Aquaporin-6 shows greatest homology with hMIP (48%) and hAQP-2 (52%). It also has similarity with human MIWC (AQP4; 34%), CHIP-28 (AQP1; 38%), and GLIP (AQP3; 22%)
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_001652.3
    Entrez基因汇总 The protein encoded by this gene is an aquaporin protein, which functions as a water channel in cells. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This protein is specific for the kidney. This gene and related family members AQP0, AQP2, and AQP5 reside in a cluster on chromosome 12q13.
    基因符号
    • Aquaporin-2-like
    • AQP6
    • hKID
    • AQP2L
    • KID
    • Aquaporin-6
    • AQP-6
    UniProt编号
    • Q13520
    UniProt汇总 FUNCTION: SwissProt: Q13520 # Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism (By similarity).
    SIZE: 282 amino acids; 29563 Da
    SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity).
    DOMAIN:SwissProt: Q13520 Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
    SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain frozen at -20°C in undiluted aliquots for up to 12 months.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB3073,Anti-Aquaporin 6 Antibody, kidney specific form

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