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- 体外诊断/OEM材料和试剂
- 产品介绍
描述 产品目录编号 CBL212-KC 品牌系列 Chemicon®
商名 - Chemicon
描述 Neurofilament 200 MS x HU (KC) MG 概述 This product is intended for use by IVD manufacturers. 产品信息 格式 Purified 演示 The monoclonal is presented in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application. 应用 主要应用 - Immunohistochemistry
应用说明 Staining of both frozen and paraffin wax embedded tissue sections
Strong staining of neuronal processes in a variety of tissues
Optimal working dilutions must be determined by the end user.生物信息 克隆 RT97 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 The clone RT97 recognizes the 200 kDa neurofilament polypeptide in a number of mammalian and avian species. Tumours specifically recognized include phaeochromocytoma, paraganglioma, ganglioneuroblastoma and other tumours of neuronal origin.
KNOWN SPECIES CROSS REACTIVITY: Recognizes rat, chicken, pig and reptile同种型 IgG1 品种反应性 ReptileAvianChickenHumanMammalsPigRat 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_021076.2
基因符号 - KIAA0845
- NEFH
- NF-H
- NFH
UniProt编号 - P12036
UniProt汇总 FUNCTION: SwissProt: P12036 # Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.
SIZE: 1026 amino acids; 112480 Da
PTM: There are a number of repeats of the tripeptide K-S-P, NFH is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFH results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. & Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function.
DISEASE: SwissProt: P12036 # Defects in NEFH are a cause of susceptibility to amyotrophic lateral sclerosis (ALS) [MIM:105400]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.
SIMILARITY: SwissProt: P12036 ## Belongs to the intermediate filament family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C for up to one year. 包装信息 数量 Bulk packaging. Please inquire.
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