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  • merck millipore,默克密理博,AB3834,Anti-PAK1 (Ser199/204)/PAK2 (Ser192/197) Antibody, phospho-specific

  • merck millipore,默克密理博,AB3834,Anti-PAK1 (Ser199/204)/PAK2 (Ser192/197) Antibody, phospho-specific

    产品名称：Anti-PAK1 (Ser199/204)/PAK2 (Ser192/197) Antibody, phospho-specific
    产品型号：AB3834
    Anti-PAK1 (Ser199/204)/PAK2 (Ser192/197) Antibody, phospho-specific detects level of PAK1 (Ser199/204)/PAK2 (Ser192/197) & has been published & validated for use in WB.

    merck millipore,默克密理博,AB3834,Anti-PAK1 (Ser199/204)/PAK2 (Ser192/197) Antibody, phospho-specific

  • 产品介绍
  • merck millipore,默克密理博,AB3834,Anti-PAK1 (Ser199/204)/PAK2 (Ser192/197) Antibody, phospho-specific

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB3834
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-PAK1 (Ser199/204)/PAK2 (Ser192/197) Antibody, phospho-specific
    Alternate Names
    • p65-PAK
    • p21-activated Kinase 1
    产品信息
    格式 Affinity Purified
    演示 Liquid in 10 mM sodium HEPES, pH 7.5, 150 mM NaCl, 100 μg/ml BSA, with 50% glycerol.
    应用
    应用 Anti-PAK1 (Ser199/204)/PAK2 (Ser192/197) Antibody, phospho-specific detects level of PAK1 (Ser199/204)/PAK2 (Ser192/197) & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    应用说明 Western blotting 1:1,000 (for best results, incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight). The antibody detects a single band migrating at approximately 65 kDa corresponding to PAK1.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 KLH-conjugated, synthetic phospho-peptide corresponding to residues surrounding Ser199/204 of human PAK1.
    表位 phospho-specific
    宿主 Rabbit
    特异性 Recognizes Ser199/204 phosphorylated PAK1 or Ser192/197 phosphorylated PAK2. It may also detect Ser200/205 phosphorylated PAK3, however it does not cross-react with phosphorylated PAK4. The p21-activated kinase (PAK) family of serine/threonine kinases is engaged in multiple cellular processes, including cytoskeletal reorganization, MAPK signaling, apoptotic signaling, control of phagocyte NADPH oxidase and growth factor-induced neurite outgrowth.

    SPECIES REACTIVITIES:

    Human and guinea pig, predicted to react with rat and mouse due to 100% sequence homology.
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002576.3
    Entrez基因汇总 The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
    基因符号
    • EC 2.7.11.1
    • PAK1
    • MGC130001
    • Alpha-PAK
    • MGC130000
    • PAK-1
    • PAKalpha
    • p65-PAK
    修改
    • Phosphorylation
    UniProt编号
    • Q13177
    • Q13153
    UniProt汇总 FUNCTION: SwissProt: Q13177 # The activated kinase acts on a variety of targets. Phosphorylates ribosomal protein S6, histone H4 and myelin basic protein. Full length PAK 2 stimulates cell survival and cell growth. The process is, at least in part, mediated by phosphorylation and inhibition of pro-apoptotic BAD. Caspase- activated PAK-2p34 is involved in cell death response, probably involving the JNK signaling pathway. Cleaved PAK-2p34 seems to have a higher activity than the CDC42-activated form.
    SIZE: 524 amino acids; 58043 Da
    SUBUNIT: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with SH3MD4. Interacts with and activated by HIV-1 Nef. PAK-2p34 interacts with ARHGAP10.
    SUBCELLULAR LOCATION: Serine/threonine-protein kinase PAK 2: Cytoplasm. & PAK-2p34: Nucleus. Cytoplasm, perinuclear region. Membrane; Lipid-anchor. Note=Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane.
    TISSUE SPECIFICITY: Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen.
    PTM: Full length PAK 2 is autophosphorylated when activated by CDC42/p21. Following cleavage, both peptides, PAK-2p27 and PAK- 2p34, become highly autophosphorylated, with PAK-2p27 being phosphorylated on serine and PAK-2p34 on threonine residues, respectively. Autophosphorylation of PAK-2p27 can occur in the absence of any effectors and is dependent on phosphorylation of Thr-402, because PAK-2p27 is acting as an exogenous substrate. & During apoptosis proteolytically cleaved by caspase-3 or caspase-3-like proteases to yield active PAK-2p34. & Ubiquitinated, leading to its proteosomal degradation. & PAK-2p34 is myristoylated.
    SIMILARITY: SwissProt: Q13177 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CRIB domain. & Contains 1 protein kinase domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20ºC for 12 months, do not aliquot.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB3834,Anti-PAK1 (Ser199/204)/PAK2 (Ser192/197) Antibody, phospho-specific

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