merck millipore,默克密理博,681675,Wortmannin - CAS 19545-26-7

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merck millipore,默克密理博,681675,Wortmannin - CAS 19545-26-7 - Calbiochem
产品名称：Wortmannin - CAS 19545-26-7 - Calbiochem
产品型号：681675
A cell-permeable, fungal metabolite that acts as a potent, selective, and irreversible inhibitor of phosphatidylinositol 3-kinase in purified preparations and cytosolic fractions (IC₅₀ = 5 nM).

merck millipore,默克密理博,681675,Wortmannin - CAS 19545-26-7 - Calbiochem

产品介绍

merck millipore,默克密理博,681675,Wortmannin - CAS 19545-26-7 - Calbiochem

重要规格表

经验配方	CAS号
C₂₃H₂₄O₈	19545-26-7

描述
概述	A cell-permeable, fungal metabolite that acts as a potent, selective, and irreversible inhibitor of phosphatidylinositol 3-kinase in purified preparations and cytosolic fractions (IC₅₀ = 5 nM). Blocks the catalytic activity of PI 3-kinase without affecting the upstream signaling events. Preincubation of fibroblasts with wortmannin abolishes PDGF-mediated Ins(3,4,5)P₃ formation (IC₅₀ = 5 nM). Also blocks the metabolic effects of insulin in isolated rat adipocytes without affecting the insulin receptor tyrosine kinase activity. Inhibits MAP kinase activation induced by platelet activating factor in guinea pig neutrophils (200 - 300 nM). Also inhibits other kinases such as myosin light chain kinase (IC₅₀ = 200 nM) and PI 4-kinase at concentrations higher than that required for inhibition of PI 3-kinase. Also blocks phospholipase D. A 10 mM (1 mg/233 µl) solution of Wortmannin (Cat. No. 681676) in DMSO is also available.
产品目录编号	681675
品牌系列	Calbiochem®
同义词	KY 12420, MLCK Inhibitor II

参考
参考	Cross, M.J., et al. 1995. J. Biol. Chem. 270, 25352. Nakamura, I., et al. 1995. FEBS Lett. 361, 79. Ferby, I.M., et al. 1994. J. Biol. Chem. 269, 30485. Okada, T., et al. 1994. J. Biol. Chem. 269, 3568. Wymann, M.P. and Arcaro, A. 1994. Biochem. J. 298, 517. Arcaro, A. and Wymann, M.P. 1993. Biochem. J. 296, 297. Nakanishi, S., et al. 1992. J. Biol. Chem. 267, 2157. Bonser, R.W., et al. 1991. Br. J. Pharmacol. 103, 1237.

参考

Cross, M.J., et al. 1995. J. Biol. Chem. 270, 25352.
Nakamura, I., et al. 1995. FEBS Lett. 361, 79.
Ferby, I.M., et al. 1994. J. Biol. Chem. 269, 30485.
Okada, T., et al. 1994. J. Biol. Chem. 269, 3568.
Wymann, M.P. and Arcaro, A. 1994. Biochem. J. 298, 517.
Arcaro, A. and Wymann, M.P. 1993. Biochem. J. 296, 297.
Nakanishi, S., et al. 1992. J. Biol. Chem. 267, 2157.
Bonser, R.W., et al. 1991. Br. J. Pharmacol. 103, 1237.

产品信息
CAS号	19545-26-7
具有ATP竞争性	N
形式	White to off-white solid
Hill配方	C₂₃H₂₄O₈
化学配方	C₂₃H₂₄O₈
Molar Mass	428.4
可逆	N
结构配方图像

生物信息
主靶	phosphatidylinositol-3-kinase
主靶IC₅₀	5 nM against phosphatidylinositol 3-kinase; 5 nM against PDGF-mediated Ins(3,4,5)P3 formation; 200 nM against myosin light chain kinase
纯度	≥98% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO or EtOH

GHS安全信息
RTECS	CB9641000

安全信息
R相	R: 26/27/28 Very toxic by inhalation, in contact with skin and if swallowed.
S相	S: 22-36/37/39-45 Do not breathe dust. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Highly Toxic
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.