- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M ICC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB2991 描述 Anti-p32 Antibody Alternate Names - splicing factor SF2-associated protein
- C1q globular domain-binding protein
- GC1q-R protein
- Glycoprotein gC1qBP
- Hyaluronan-binding protein 1
- Mitochondrial matrix protein p32
- complement component 1, q subcomponent binding protein
背景信息 The p32 protein is a doughnut-shaped trimer that is primarily localized in the mitochondria. It has also been reported to be present at the cell surface and in the nucleus. The role of p32 in mammalian cells is unclear. The yeast p32 homologue has been reported to regulate oxidative phosphorylation, and a link to autophagy has been proposed. Elevated expression of p32 in cancer has also been noted. Additionally, p32 is primarily localized in hypoxic/nutrient-deprived regions within tumors and that, in addition to tumor cells, a tumor-associated macrophage/myeloid cell subpopulation closely linked to tumor lymphatics expresses high levels of p32. The expression of p32 at the cell surface, where it can be targeted with p32-binding antibodies and peptides, adds a second level of tumor specificity to p32 expression. The unique expression pattern of p32 in tumor cells, tumor lymphatics, and tumor-associated macrophages/myeloid cells makes p32 a potential target for the diagnosis and therapy of cancer. 产品信息 格式 Affinity Purified 控制 - A431 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 This Anti-p32 Antibody is validated for use in WB, IC for the detection of p32. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected p32 in HeLa and A431 cells. 生物信息 免疫原品种 Cocktail of peptides corresponding to the N-terminus of human and mouse p32. 表位 Unknown 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes p32. 同种型 IgG 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with human, mouse, and rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001203
Entrez基因汇总 The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. [provided by RefSeq]. 基因符号 - p33
- C1QBP
- C1qBP
- GC1QBP
- HABP1
- SF2P32
- SF2p32
- gC1Q-R
- gC1qR
- p32
纯化方法 Affinity Purfied UniProt编号 - Q07021
UniProt汇总 FUNCTION: Not known. Binds to the globular "heads" of C1Q thus inhibiting C1 activation.
SUBUNIT STRUCTURE: Interacts with Rubella virus capsid protein.
SUBCELLULAR LOCATION: Mitochondrion matrix.
SEQUENCE SIMILARITIES: Belongs to the MAM33 family.
CAUTION: Was originally thought to be a pre-mRNA splicing factor SF2 p32 subunit and to play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing.产品使用声明 质量保证 Evaluated by Western Blot in A431 cell lysate.
Western Blot Analysis: 0.5 µg/ml of this antibody detected p32 on 10 µg of A431 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,07-702,Anti-FOXO3a/FKHRL1 Antibody
下一件merck millipore产品：merck millipore,默克密理博,MABF202,Anti-Kininogen-1 Antibody, clone EPR6097, rabbit monoclonal
相关产品
merck millipore,默克密理博,AB6010,Anti-MMP-12 Antibody, NT (active)
merck millipore,默克密理博,71364,pRSF-2 Ek/LIC Vector Kit - Novagen
![merck millipore,默克密理博,108602,N-[叁(羟甲)甲基]甘胺酸](/e/upload/m_pic/MM_watermark%5BMM_watermark-ALL%5D.jpg "merck millipore,默克密理博,108602,N-[叁(羟甲)甲基]甘胺酸")
merck millipore,默克密理博,108602,N-[叁(羟甲)甲基]甘胺酸
%5BABN208_IHC(P)-ALL%5D.jpg "merck millipore,默克密理博,ABN208,Anti-ARLIP6 Antibody")
merck millipore,默克密理博,ABN208,Anti-ARLIP6 Antibody
merck millipore,默克密理博,07-702,Anti-FOXO3a/FKHRL1 Antibody
merck millipore,默克密理博,MABF202,Anti-Kininogen-1 Antibody, clone EPR6097, rabbit monoclonal
merck millipore,默克密理博,06-109,Anti-IGFBP-4 Antibody
merck millipore,默克密理博,04-1530,Anti-MDM2 Antibody, clone 3G9
merck millipore,默克密理博,07-748,Anti-monomethyl-Histone H4 (Lys20) Antibody
merck millipore,默克密理博,SF-763,IL8; Human, Cyanine 5 RNA Detection Probe,SmartFlare