merck millipore,默克密理愽
  • merck millipore,默克密理博,AB2208,Anti-phospho STEP61/46 Antibody, (Ser221/Ser49)

  • merck millipore,默克密理博,AB2208,Anti-phospho STEP61/46 Antibody, (Ser221/Ser49)

    产品名称：Anti-phospho STEP61/46 Antibody, (Ser221/Ser49)
    产品型号：AB2208
    Anti-phospho STEP61/46 Antibody, (Ser221/Ser49) is an antibody against phospho STEP61/46 for use in WB, IH.

    merck millipore,默克密理博,AB2208,Anti-phospho STEP61/46 Antibody, (Ser221/Ser49)

  • 产品介绍
  • merck millipore,默克密理博,AB2208,Anti-phospho STEP61/46 Antibody, (Ser221/Ser49)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, M, H, Rhesus Macaque, BIHC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB2208
    描述 Anti-phospho STEP61/46 Antibody, (Ser221/Ser49)
    Alternate Names
    • Neural-specific protein-tyrosine phosphatase
    • protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
    • protein-tyrosine phosphatase striatum-enriched
    • tyrosine-protein phosphatase non-receptor type 5
    • Striatum-enriched protein-tyrosine phosphatase
    背景信息 Striatum-enriched protein-tyrosine phosphatase (STEP) isoforms 61 and 46 are two of the many splice variants for STEP, a protein belonging to the protein-tyrosine phosphatase family and containing a single tyrosine-protein phosphatase domain. STEP61 is membrane-associated, where as STEP46 is cytosolic. STEP61 also differs in that it contains a sequence of 172 amino acids with structural motifs not found in STEP46. Both isoforms are phosphorylated on serine residues, although STEP61 is mainly phosphorylated at Ser160 and Ser221, while STEP46 is phosphorylated at Ser49. STEP is thought to have a critical role in regulating dopamine efficacy on striatial medium spiny neurons, neurotransmission through the NMDAR pathway, and AMPA receptor endocytosis.
    产品信息
    格式 Affinity Purified
    控制
    • Mouse brain tissue lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-phospho STEP61/46 Antibody, (Ser221/Ser49) is an antibody against phospho STEP61/46 for use in WB, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: 1:600 dilution of this antibody from a previous lot detected phosphorylated STEP61/46 in caudata putamen region of adult human brain tissue.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to mouse STEP61/46 phosphorylated at Ser221/Ser49.
    表位 Phosphorylated Ser221/Ser49
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes STEP61/46 when phosphorylated at Ser221/Ser49.
    品种反应性 RatMouseHumanRhesus MacaqueBovine
    Species Reactivity Note Demonstrated to react with human and mouse. Predicted to react with rhesus monkey, bovine, and rat based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_001157037
    基因符号
    • FLJ14427
    • STEP
    • PTPSTEP
    • PTPN5
    纯化方法 Affinity purified
    UniProt编号
    • P54830
    UniProt汇总 CATALYTIC ACTIVITY: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    TISSUE SPECIFICTY: STEP20 is expressed only in the CNS.

    SEQUENCE SIMILARITIES: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

    Contains 1 tyrosine-protein phosphatase domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in mouse brain tissue lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected STEP61/46 on 10 µg of mouse brain tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB2208,Anti-phospho STEP61/46 Antibody, (Ser221/Ser49)

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下一件merck millipore产品：merck millipore,默克密理博,AB758,Anti-Collagen Type I Antibody


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