merck millipore,默克密理愽
  • merck millipore,默克密理博,401479,IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem

  • merck millipore,默克密理博,401479,IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem

    产品名称：IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem
    产品型号：401479
    The IKK-2 Inhibitor, SC-514, also referenced under CAS 354812-17-2, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

    merck millipore,默克密理博,401479,IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,401479,IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₉H₈N₂OS₂354812-17-2
    描述
    概述 A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 = ~ 3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 µM). Shown to specifically block NF-κB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF. A 25 mM (1 mg/178 µl) solution of IKK-2 Inhibitor, SC-514 (Cat. No. 401485) in DMSO is also available.
    产品目录编号 401479
    品牌系列 Calbiochem®
    同义词 SC-514
    参考
    参考 Baxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
    Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.
    产品信息
    CAS号 354812-17-2
    具有ATP竞争性 Y
    形式 Pale yellow solid
    Hill配方 C₉H₈N₂OS₂
    化学配方 C₉H₈N₂OS₂
    Molar Mass 224.3
    可逆 Y
    结构配方图像
    生物信息
    主靶 IKK-2
    主靶IC50 3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Carcinogenic / Teratogenic
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,401479,IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem

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