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品种反应性 主要应用 宿主 格式 抗体类型 M WB M Purified Monoclonal Antibody 描述 产品目录编号 MABN155 描述 Anti-Sox1 Antibody, clone 2B3.3 Alternate Names - Transcription factor SOX-1
背景信息 SRY (Sex determining region Y)-box 1(Sox1), is a transcription factor that is expressed in the developing brain. SOX1 is related to the HMG box of family transcription factors, which are a highly motile group, with a highly conserved DNA binding domain. Sox1 utilizes multiple pathways to play a direct role on cell fate. Sox1 is also directly involved with sex determination of the Y chromosome. Binding of the Sox1, C-terminus, to the Hes 1 promoter results in Hes1 suppression and attenuation of Notch signaling. When the C-terminus of Sox1 binds to β-catenin, TCF/LEF is suppressed, resulting in the attenuation of Wnt signaling. Sox1 may function as a switch in neuronal development. 产品信息 格式 Purified 控制 - Mouse neuronal stem cell lysate
演示 Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. 应用 应用 Detect the Sox1 protein using this Anti-Sox1, clone 2B3.3 validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Sox1. 克隆 2B3.3 宿主 Mouse 同种型 IgMκ 品种反应性 Mouse Species Reactivity Note Demonstrated to react with Mouse. Predicted to react with Human based on immunogen design. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_005977
基因符号 - SOX1
纯化方法 Purified by ion-exchange chromatography UniProt编号 - O00570
产品使用声明 质量保证 Evaluated by Western Blot in mouse neuronal stem cell lysate.
Western Blot Analysis: A 1:500 dilution of this antibody detected Sox1 in 200 µg of mouse neuronal stem cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 200 µL
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下一件merck millipore产品：merck millipore,默克密理博,71009,CytoBuster™ Protein Extraction Reagent
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