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merck millipore,默克密理博,AB1797P,Anti-Arginine Vasopressin Receptor V2 Antibody
产品名称：Anti-Arginine Vasopressin Receptor V2 Antibody
产品型号：AB1797P
Anti-Arginine Vasopressin Receptor V2 Antibody is an antibody against Arginine Vasopressin Receptor V2 for use in ELISA, IH & WB.
merck millipore,默克密理博,AB1797P,Anti-Arginine Vasopressin Receptor V2 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R WB, ELISA, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB1797P Replaces AB3512P 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Arginine Vasopressin Receptor V2 Antibody Alternate Names - AVPR-V2
产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Liquid in PBS containing 0.1% BSA. 应用 应用 Anti-Arginine Vasopressin Receptor V2 Antibody is an antibody against Arginine Vasopressin Receptor V2 for use in ELISA, IH & WB. 主要应用 - Western Blotting
- ELISA
- Immunohistochemistry
应用说明 Western blot: 1-10 μg/mL using ECL. An antibody raised against this peptide has detected a glycosylated band at ~62 kDa in membranes from rat inner medulla (Nonoguchi et al. 1995). N-Glycanase reduced the size to ~36 kDa (deglycosylated form).
Immunohistochemistry: 2-10 μg/mL on paraformaldehyde fixed tissue. AVP-V2 has been localized in terminal IMCD and other areas of rat kidney (Nonoguchi et al. 1995).
ELISA: 0.5-1.0 μg/mL using 1 μg/mL of control peptide to coat plate.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 21 amino acid peptide from the 3rd cytoplasmic domain of rat AVP-V2 (Lolait et al. 1992; Fisov et al. 1994). 宿主 Rabbit 特异性 Arginine vasopressin receptor (AVP-V2), rat. The peptide used for immunization has no significant similarity with AVP V1a or V1b receptors. 品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000054.2
Entrez基因汇总 This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. 基因符号 - NDI
- AVPR2
- DI1
- V2R
- DIR
- MGC138386
- MGC126533
- DIR3
- ADHR
UniProt编号 - P30518
UniProt汇总 FUNCTION: SwissProt: P30518 # Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
SIZE: 371 amino acids; 40279 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Kidney.
DISEASE: SwissProt: P30518 # Defects in AVPR2 are the cause of nephrogenic syndrome of inappropriate antidiuresis (NSIAD) [MIM:300539]. This disorder is characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis. & Defects in AVPR2 are a cause of X-linked nephrogenic diabetes insipidus, type I (NDI) [MIM:304800]. It is characterized by excessive water drinking (polydypsia) and urine excretion (polyuria) and fail to concentrate urine in response to vasopressin. Most cases of NDI appear to have an X-linked recessive pattern of inheritance.
SIMILARITY: SwissProt: P30518 ## Belongs to the G-protein coupled receptor 1 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to six months. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µg
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