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品种反应性 主要应用 宿主 格式 抗体类型 H, M, R IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABN97 描述 Anti-Neurexin2 Antibody Alternate Names - Neurexin II-alpha
- Neurexin-2-alpha
背景信息 Neurexins are heavily glycosylated and processed neuronal transmembrane cell surface proteins likely involved in cell recognition and adhesion. (Missler, M., et al. (1998) 14(1):20-26.) Antibody Anti-neurexin 2 alpha (ABN97) was made against a peptide immunogen corresponding to a stretch of amino acids in the extracellular domain of human neurexin 2 alpha (Uniprot Q9P2S2). Although the theoretical full length of Neurexin 1alpha is 185 kDa, the protein detected in human, mouse and rat brain lysates shows a band around 70-80 kDa as a possible result of the posttranslational processing previously reported. 产品信息 格式 Affinity Purified 控制 - PC12 tissue lysate.
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-Neurexin2 Antibody is validated for use in WB, IH for the detection of Neurexin2. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:200 dilution from a representative lot detected Neurexin-2 in normal rat brain. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Neurexin-2. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 HumanMouseRat Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_055895
Entrez基因汇总 This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants. 基因符号 - KIAA0921
- NRXN2
纯化方法 Affinity purified UniProt编号 - Q9P2S2
UniProt汇总 FUNCTION: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.
SUBUNIT STRUCTURE: The laminin G-like domain 1 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan. Interacts with INADL.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.产品使用声明 质量保证 Evaluated by Western Blot in PC12 tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Neurexin-2 in PC12 tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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