merck millipore,默克密理博,16-257,Anti-IRS1 Antibody, Alexa Fluor 488 conjugate

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

当前位置：首页 > >Merck Millipore > 生命科学研究
生命科学研究

merck millipore,默克密理博,16-257,Anti-IRS1 Antibody, Alexa Fluor 488 conjugate
产品名称：Anti-IRS1 Antibody, Alexa Fluor 488 conjugate
产品型号：16-257
Detect IRS1 using this Anti-IRS1 Antibody, Alexa Fluor 488 conjugate validated for use in FC, IC & IF.

merck millipore,默克密理博,16-257,Anti-IRS1 Antibody, Alexa Fluor 488 conjugate

产品介绍

merck millipore,默克密理博,16-257,Anti-IRS1 Antibody, Alexa Fluor 488 conjugate

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	ICC, FC	Rb	AlexaFluor®488	Polyclonal Antibody

描述
产品目录编号	16-257
品牌系列	Upstate
商名	Upstate
描述	Anti-IRS1 Antibody, Alexa Fluor® 488 conjugate

产品信息
格式	AlexaFluor®488

应用
应用	Detect IRS1 using this Anti-IRS1 Antibody, Alexa Fluor 488 conjugate validated for use in FC, IC & IF.
主要应用	Immunocytochemistry Flow Cytometry

生物信息
免疫原品种	c-terminal 14 amino acid peptide ([C]-ASINFQKQPEDRQ) of rat liver IRS1
宿主	Rabbit
特异性	IRS1
同种型	IgG
品种反应性	RatHumanMouse
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_005544.1
基因符号	HIRS-1 IRS1 IRS-1
纯化方法	Immunoaffinity purified
UniProt编号	P35568
UniProt汇总	FUNCTION: SwissProt: P35568 # May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). SIZE: 1242 amino acids; 131591 Da SUBUNIT: Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR via the PTB domain. Binds to phosphatidylinositol 3-kinase p85 subunit via the phosphorylated YXXM motifs. Binds ROCK1. Binds to UBTF and PIK3CA in nuclear extracts (By similarity). Interacts with SOCS7. PTM: Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). & Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity).DISEASE:SwissProt: P35568 # Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. SIMILARITY: SwissProt: P35568 ## Contains 1 IRS-type PTB domain. & Contains 1 PH domain.

产品使用声明
质量保证	Routinely evaluated by flow cytometry on fixed and permeabilized HeLa cells
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. Alexa Fluor® is a registered trademark of Molecular Probes, Inc.

产品使用声明

质量保证

Routinely evaluated by flow cytometry on fixed and permeabilized HeLa cells

使用声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc.