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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-1424 Replaces AB10602 描述 Anti-VEGF-C (Mature) Antibody Alternate Names - vascular endothelial growth factor isoform VEGF165
- Vascular permeability factor
- vascular endothelial growth factor
- vascular endothelial growth factor C
背景信息 Vascular endothelial growth factors (VEGFs), a group of structurally and functionally related growth factors, may play important roles in vascular system formation during embryonic development, the regulation of capillary growth in adults, and the maintenance of normal vasculature. It is a ligand for the receptor tyrosine kinases VEGFR-3 and VEGFR2, both of which are expressed by endothelial cells. VEGF-C mRNA has been detected in human heart, placenta, muscle, ovary, and small intestine, as well as in malignant tissues. In addition, VEGF-C mRNA expression was detected in over 50% of tumor specimens studied. 产品信息 格式 Affinity Purified 控制 - HUVEC cell lysate
演示 Purified rabbit polyclonal in buffer containing phosphate buffered saline (pH 7.4) and 0.05% sodium azide 应用 应用 Detect VEGF-C (Mature) using this Anti-VEGF-C (Mature) Antibody validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Synthetic peptide corresponding to human VEGF-C. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the mature form of human VEGF-C in addition to the various forms along the proteolytic process (43, 58, and 61 kDa). 品种反应性 Human Species Reactivity Note Reacts with human, mouse and rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_005420.1
Entrez基因汇总 The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D. 基因符号 - VPF
- MGC70609
- MVCD1
- VEGF
- VEGF-C
纯化方法 Affinity Purfied UniProt编号 - P49767
UniProt汇总 FUNCTION: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to VEGFR2/Kdr but doesn't activate downstream signaling pathways, doesn't activate angiogenesis and inhibits tumor growth.
SUBUNIT STRUCTURE: Homodimer; disulfide-linked. Also found as heterodimer with PlGF By similarity.
SUBCELLULAR LOCATION: Secreted. Note: VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
TISSUE SPECIFICITY: The VEGF189, VEGF-165 and VEGF-121 isoforms are widely expressed, whereas the VEGF206 and VEGF-145 are uncommon.
INDUCTION: Regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoxia, hypoglycemia and oncogenic mutations.
SEQUENCE SIMILARITIES: Belongs to the PDGF/VEGF growth factor family.
SEQUENCE CAUTION: The sequence CAC19512.2 differs from that shown. Reason: Erroneous gene model prediction.产品使用声明 质量保证 Evaluated by Western Blot in HUVEC cell lysate.
Western Blot Analysis: 1:500 dilution of this antibody detected VEGF-C on 10 µg of HUVEC cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µg
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