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merck millipore,默克密理博,AB15562-200UL,Anti-Transient Receptor Potential Channel 7 Antibody
产品名称：Anti-Transient Receptor Potential Channel 7 Antibody
产品型号：AB15562-200UL
This Anti-Transient Receptor Potential Channel 7 Antibody is validated for use in IC, WB for the detection of Transient Receptor Potential Channel 7.
merck millipore,默克密理博,AB15562-200UL,Anti-Transient Receptor Potential Channel 7 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, M WB, ICC Rb Purified Polyclonal Antibody 描述 产品目录编号 AB15562-200UL 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Transient Receptor Potential Channel 7 Antibody Alternate Names - TRPM7, LTRPC7, Channel-kinase 1
- TRPM7
- LTRPC7
产品信息 格式 Purified 控制 - Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
演示 Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative. Reconstitute with 200 uL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). 应用 应用 This Anti-Transient Receptor Potential Channel 7 Antibody is validated for use in IC, WB for the detection of Transient Receptor Potential Channel 7. 主要应用 - Western Blotting
- Immunocytochemistry
应用说明 Western blot: 1:200-1:500 using ECL on mouse brain lysate and GH3 cell line (rat pituitary tumor) lysate.
Immunocytochemistry: 1:200 using GH3 cell line (rat pituitary tumor).
Dilutions should be made using a carrier protein such as BSA (1-3%).
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Purified peptide from the C-terminus of human TRPM7 (Accession number Q96QT4). 宿主 Rabbit 特异性 Recognizes Transient Receptor Potential Channel 7 (TRPM7, LTRPC7, Channel-kinase 1). 品种反应性 RatMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_017672.3
Entrez基因汇总 TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.[supplied by OMIM] 基因符号 - EC 2.7.11.1
- TRPM7
- TRP-PLIK
- LTRPC7
- LTrpC7
- FLJ20117
- CHAK
- FLJ25718
- CHAK1
纯化方法 Immunoaffinity purified UniProt编号 - Q96QT4
UniProt汇总 FUNCTION: SwissProt: Q96QT4 # Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
COFACTOR: Binds 1 zinc ion per subunit (By similarity).
SIZE: 1865 amino acids; 212697 Da
SUBUNIT: Homodimer (By similarity). Forms heterodimers with TRPM6.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable).
PTM: Autophosphorylated (By similarity).
DISEASE: SwissProt: Q96QT4 # Defects in TRPM7 influences susceptibility to amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 [MIM:105500]; also called amyotrophic lateral sclerosis- parkinsonism/dementia complex of Guam or Guam disease. Amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 is a neurodengenerative disorder with unusually high incidence among the Chamorro people of the Western Pacific Islands of Guam. Both amyotrophic lateral sclerosis and parkinsonism-dementia are chronic, progressive, and uniformly fatal disorders in this population. Both diseases are known to occur in the same kindred, the same sibship, and even the same individual.
SIMILARITY: SwissProt: Q96QT4 ## In the N-terminal section; belongs to the transient receptor family. LTrpC subfamily. & Contains 1 alpha-type protein kinase domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 200 µL
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