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  • merck millipore,默克密理博,MAB3104,Anti-Calpain I Antibody, large subunit, clone P9

  • merck millipore,默克密理博,MAB3104,Anti-Calpain I Antibody, large subunit, clone P9

    产品名称：Anti-Calpain I Antibody, large subunit, clone P9
    产品型号：MAB3104
    Anti-Calpain I Antibody, large subunit, clone P9 is an antibody against Calpain I for use in ELISA, IP, WB & IC.

    merck millipore,默克密理博,MAB3104,Anti-Calpain I Antibody, large subunit, clone P9

  • 产品介绍
  • merck millipore,默克密理博,MAB3104,Anti-Calpain I Antibody, large subunit, clone P9

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, Ht, MICC, ELISA, WBMAscitesMonoclonal Antibody
    描述
    产品目录编号 MAB3104
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Calpain I Antibody, large subunit, clone P9
    Alternate Names
    • μ-Calpain
    • mu-Calpain
    背景信息 Calpains are non-lysosomal cysteine proteeases which absolutely require calcium for activity. There are two major calpain isozymes: μ-calpain and m-calpain, which require micromolar or millimolar calicum for activity, respectively, in invitro assays. The major calpain isozymes are composed of two subunits: an 80kDa catalytic subunit; and a 30kDa regulatory subunit. The large and small subunits remain associated in the presence of calcium after proteolytic activation of the zymogen.
    产品信息
    格式 Ascites
    控制
    • WI-38 human fibroblasts, or human erthryocytes are suggested as positive controls.
    演示 Liquid
    应用
    应用 Anti-Calpain I Antibody, large subunit, clone P9 is an antibody against Calpain I for use in ELISA, IP, WB & IC.
    主要应用
    • Immunocytochemistry
    • ELISA
    • Western Blotting
    应用说明 Immunoblot: 1:1,000 Detects an 80kDa large subunit μ-calpain, and will also detect the subunit in the non-activated proform of the zymogen, showing a band of ~110kDa. WI-38 human fibroblasts, or human erthryocytes are suggested as positive controls. Immunocytochemistry: 1:100 on A431 epidermal carcinoma.

    Immunoprecipitation

    ELISA: 1:6,000 (against the immunogen)

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Calpain-I large subunit from human erythrocyte calpain.
    表位 large subunit
    克隆 P9
    宿主 Mouse
    特异性 Reacts with human calpain-I (μ-Calpain). P9 does not cross with human placental m-calpain (calpain II). This antibody will immunoprecipitate proteolytically active calpains.
    同种型 IgG1
    品种反应性 RatHumanHamsterMouse
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_005186.2
    Entrez基因汇总 The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1.
    基因符号
    • EC 3.4.22.52
    • CAPN1
    • CANPL1
    • muCANP
    • CANP
    • muCL
    • Micromolar-calpain
    非反应性品种
    • Canine
    UniProt编号
    • P07384
    UniProt汇总 FUNCTION: SwissProt: P07384 # Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
    COFACTOR: Binds 3 calcium ions.
    SIZE: 714 amino acids; 81890 Da
    SUBUNIT: Forms a heterodimer with a small (regulatory) subunit (CAPNS1).
    SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Translocates to the plasma membrane upon Ca(2+) binding (By similarity).
    TISSUE SPECIFICITY: Ubiquitous.
    SIMILARITY: SwissProt: P07384 ## Belongs to the peptidase C2 family. & Contains 1 calpain catalytic domain. & Contains 4 EF-hand domains.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB3104,Anti-Calpain I Antibody, large subunit, clone P9

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