merck millipore,默克密理愽
  • merck millipore,默克密理博,219673,CFTR-F508del Corrector II, Corr-4a - CAS 421580-53-2 - Calbiochem

  • merck millipore,默克密理博,219673,CFTR-F508del Corrector II, Corr-4a - CAS 421580-53-2 - Calbiochem

    产品名称：CFTR-F508del Corrector II, Corr-4a - CAS 421580-53-2 - Calbiochem
    产品型号：219673
    A cell-permeable bisaminomethylbithiazole compound that is reported to rescue/correct the folding defect of CFTR δF508 mutant via direct interaction.

    merck millipore,默克密理博,219673,CFTR-F508del Corrector II, Corr-4a - CAS 421580-53-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,219673,CFTR-F508del Corrector II, Corr-4a - CAS 421580-53-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₁H₁₇ClN₄O₂S₂421580-53-2
    描述
    概述 A cell-permeable bisaminomethylbithiazole compound that is reported to rescue/correct the folding defect of CFTR ΔF508 mutant via direct interaction and promote proper trafficking/glycosylation and surface expression in both transfected cells and primary airway epithelial cells from ΔF508-homozygous patients, while exhibiting little correcting effect toward N1303K-CFTR, P574H-CFTR, M345T-DRD4 (dopamine receptor 4), or G268V-ABCA1/CD243 /MDR1/ P-gp mutant. Reported to enhance the folding efficiency of both ΔF508 (by 3-fold at 10µM in FRT cells) and wild-type CFTR (by up to 70%), delay the ER-associated degradation of the core-glycosylated ΔF508 (by 30% at 10µM in FRT cells), and increase the stability of low-temperature resuced ΔF508 mutant on the plasma membrane (by 1.7-fold at 10µM in FRT cells). Corr-4a is shown to be more effective than VRT-325/CFcor-325 n restoring forskolin-stimulated CFTR activity in FRT and A549 ΔF508-CFTR transfectants. Unlike VRT-532 Corr-4a does not affect mutant CFTR channel gating activity.
    产品目录编号 219673
    品牌系列 Calbiochem®
    同义词 N-(2-(5-Chloro-2-methoxy-phenylamino)-4ʹ-methyl-[4,5ʹ]bithiazolyl-2ʹ-yl)-benzamide, Corr-4, Cystic Fibrosis Transmembrane Conductor Regulator Mutant Corrector II
    参考
    参考 Pedemonte, N., et al. 2010. Am. J. Physiol. Cell Physiol. 298, C866.
    Young, A., et al. 2009. Biochem. J. 421, 377.
    Wang, Y., et al. 2007. J. Biol. Chem. 282, 33247.
    Wang, Y., et al. 2007. Mol. Pharmacol. 71, 751.
    Wang, Y., et al. 2007. Biochem. J. 406, 257.
    Pedemonte, N., et al. 2005. J. Clin. Invest. 115, 2564.
    产品信息
    CAS号 421580-53-2
    形式 Light beige solid
    Hill配方 C₂₁H₁₇ClN₄O₂S₂
    化学配方 C₂₁H₁₇ClN₄O₂S₂
    Molar Mass 457.
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,219673,CFTR-F508del Corrector II, Corr-4a - CAS 421580-53-2 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,AB6065,Anti-Fibulin-5 Antibody
下一件merck millipore产品：merck millipore,默克密理博,MAB5386,Anti-Nerve Growth Factor Receptor (p75) Antibody, clone ME20.4


相关产品

merck millipore,默克密理博,MAB3104,Anti-Calpain I Antibody, large subunit, clone P9 merck millipore,默克密理博,MAB3104,Anti-Calpain I Antibody, large subunit, clone P9

merck millipore,默克密理博,AB15562-200UL,Anti-Transient Receptor Potential Channel 7 Antibody merck millipore,默克密理博,AB15562-200UL,Anti-Transient Receptor Potential Channel 7 Antibody

merck millipore,默克密理博,324892,eIF2-GTP-tRNAiMet ternary complex Inhibitor, BTdCPU - CAS 1257423-87-2 - Calbiochem merck millipore,默克密理博,324892,eIF2-GTP-tRNAiMet ternary complex Inhibitor, BTdCPU - CAS 1257423-87-2 - C...

merck millipore,默克密理博,SCGVT05RE,Steritop-GV，0.22 µm，PVDF，500 mL 45 mm，射线灭菌 merck millipore,默克密理博,SCGVT05RE,Steritop-GV，0.22 µm，PVDF，500 mL 45 mm，射线灭菌

merck millipore,默克密理博,AB6065,Anti-Fibulin-5 Antibody merck millipore,默克密理博,AB6065,Anti-Fibulin-5 Antibody

merck millipore,默克密理博,MAB5386,Anti-Nerve Growth Factor Receptor (p75) Antibody, clone ME20.4 merck millipore,默克密理博,MAB5386,Anti-Nerve Growth Factor Receptor (p75) Antibody, clone ME20.4

merck millipore,默克密理博,05-825R,Anti-PDGFR-β Antibody, clone 4A56, rabbit monoclonal merck millipore,默克密理博,05-825R,Anti-PDGFR-β Antibody, clone 4A56, rabbit monoclonal

merck millipore,默克密理博,AB15690,Anti-Orexin A Antibody merck millipore,默克密理博,AB15690,Anti-Orexin A Antibody

merck millipore,默克密理博,05-929,Anti-p19ARF Antibody, clone 5-C3-1 merck millipore,默克密理博,05-929,Anti-p19ARF Antibody, clone 5-C3-1

merck millipore,默克密理博,178680,L(+)Arabinose - CAS 87-72-9 - Calbiochem merck millipore,默克密理博,178680,L(+)Arabinose - CAS 87-72-9 - Calbiochem


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部