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merck millipore,默克密理博,324892,eIF2-GTP-tRNAiMet ternary complex Inhibitor, BTdCPU - CAS 1257423-87-2 - Calbiochem
产品名称：eIF2-GTP-tRNAiMet ternary complex Inhibitor, BTdCPU - CAS 1257423-87-2 - Calbiochem
产品型号：324892
The eIF2-GTP-tRNAiMet ternary complex Inhibitor, BTdCPU, also referenced under CAS 1257423-87-2, controls the biological activity of eIF2-GTP-tRNAiMet terna More>>
merck millipore,默克密理博,324892,eIF2-GTP-tRNAiMet ternary complex Inhibitor, BTdCPU - CAS 1257423-87-2 - Calbiochem
- 产品介绍
- merck millipore,默克密理博,324892,eIF2-GTP-tRNAiMet ternary complex Inhibitor, BTdCPU - CAS 1257423-87-2 - Calbiochem
重要规格表
经验配方 CAS号 C₁₃H₈Cl₂N₄OS 1257423-87-2 描述 概述 A cell-permeable N, N'-diarylurea that acts as an inhibitor of the formation of the ternary complex of eukaryotic translation initiation factor 2 (eIF2), GTP and the initiator methionine tRNA (Met-tRNAi), a key regulatory step of translation initiation. It directly activates heme-regulated inhibitor kinase (HRI), which then phosphorylates eIF2α in cells at 10 µM and in cell-free extracts dose-dependently, and thereby prevents respective ternary complex formation without elevating oxidative stress. The sensitivities of various cancer cell lines to the anti-proliferative effects of this compound are shown to correlate with the expression of HRI. Furthermore, this compound displays tumor growth inhibition in a mice xenograft model of MCF-7 human breast cancer cells at 175 mg/kg, in vivo. 产品目录编号 324892 品牌系列 Calbiochem®
同义词 1-(benzo[d][1,2,3]thiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea, N,N'-diarylurea;translation initiation tenrary complex inhibitor, heme-regulated inhibitor kinase activator, BTdCPU, BTdCPU 参考 参考 Chen, T., et al. 2011. Nat. Chem. Biol. 7, 610. 产品信息 CAS号 1257423-87-2 形式 White solid Hill配方 C₁₃H₈Cl₂N₄OS 化学配方 C₁₃H₈Cl₂N₄OS Molar Mass 339.2 结构配方图像 生物信息 纯度 ≥99% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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