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  • merck millipore,默克密理博,AB15412,Anti-MAP1LC3 A Antibody

  • merck millipore,默克密理博,AB15412,Anti-MAP1LC3 A Antibody

    产品名称：Anti-MAP1LC3 A Antibody
    产品型号：AB15412
    Anti-MAP1LC3 A Antibody is an antibody against MAP1LC3 A for use in WB, IC, IH.

    merck millipore,默克密理博,AB15412,Anti-MAP1LC3 A Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB15412,Anti-MAP1LC3 A Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HIHC, WB, ICCRbSerumPolyclonal Antibody
    描述
    产品目录编号 AB15412
    Replaces MABC176
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-MAP1LC3 A Antibody
    Alternate Names
    • Microtubule-associated proteins 1A/1B light chain 3A, MAP1A/1B LC3 A, MAP1 LC3, LC3 A
    • Microtubule-associated proteins 1A/1B light chain 3A
    • MAP1A/1B LC3 A
    • MAP1 LC3
    背景信息 Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development, differentiation, growth regulation and tissue remodeling in multicellular organisms. The human MAP1LC3 protein is homologous with the rat Map1LC3 and with yeast APG8. These proteins are likely to be involved in the formation of autophagosomal vacuoles (autophagosomes).
    产品信息
    格式 Serum
    演示 Lyophilized. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative.
    应用
    应用 Anti-MAP1LC3 A Antibody is an antibody against MAP1LC3 A for use in WB, IC, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    • Immunocytochemistry
    应用说明 Western blot: 1:200-1:1,000
    Immunocytochemistry: 1:200-1:1,000
    Immunohistochemistry: 1:200-1:1,000
    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Synthetic peptide corresponding to a region within the N-terminus of human MAP1LC3 A protein.
    宿主 Rabbit
    特异性 MAP1LC3 A [Microtubule-associated proteins 1A/1B light chain 3A, MAP1A/1B LC3 A, MAP1 LC3, LC3 A].
    品种反应性 RatHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_181509.1
    • NM_032514.2
    Entrez基因汇总 MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene.
    基因符号
    • MAP1BLC3
    • MAP1LC3A
    • MAP1ALC3
    纯化方法 Serum
    UniProt编号
    • Q9H492
    UniProt汇总 FUNCTION: SwissProt: Q9H492 # Probably involved in formation of autophagosomal vacuoles (autophagosomes).
    SIZE: 121 amino acids; 14272 Da
    SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity).
    SUBCELLULAR LOCATION: Cytoplasm. Intracytoplasmic membrane; Lipid- anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes.
    TISSUE SPECIFICITY: Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.
    PTM: The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.
    SIMILARITY: SwissProt: Q9H492 ## Belongs to the MAP1 LC3 family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material frozen at -20°C to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability.
    包装信息
    数量 50 µL

    merck millipore,默克密理博,AB15412,Anti-MAP1LC3 A Antibody

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