merck millipore,默克密理博,14-518,PKCε Protein, active, 10 µg

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merck millipore,默克密理博,14-518,PKCε Protein, active, 10 µg
产品名称：PKCε Protein, active, 10 µg
产品型号：14-518
Active, N-terminal His6-tagged, recombinant PKCε, amino acids 2-end. For use in Kinase Assays.

merck millipore,默克密理博,14-518,PKCε Protein, active, 10 µg

产品介绍

merck millipore,默克密理博,14-518,PKCε Protein, active, 10 µg

描述
产品目录编号	14-518
品牌系列	Upstate
商名	Upstate
描述	PKCε Protein, active, 10 µg
概述	N-terminal His6-tagged, recombinant PKCε, amino acids 2-end PKC Lipid activator (Catalog # 20-133) is required for use.

应用
应用	Active, N-terminal His6-tagged, recombinant PKCε, amino acids 2-end. For use in Kinase Assays.
主要应用	Kinase Assay

生物信息
来源	Human PKCε expressed in Sf21 insect cells
品种	Human
特异活性	For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez基因编号	NM_005400.2
Entrez基因汇总	Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.
基因符号	nPKC-epsilon PRKCE MGC125656 PKCE MGC125657
蛋白靶	PKCε
纯化方法	Ni²⁺/NTA-agarose
靶子系列	AGC
UniProt编号	Q02156
UniProt汇总	FUNCTION: SwissProt: Q02156 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. SIZE: 737 amino acids; 83674 Da SUBUNIT: Forms a ternary complex with TRIM63 and GN2BL1 (By similarity). DOMAIN: SwissProt: Q02156 The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain. PTM: Phosphorylation on Thr-566 by PDPK1 triggers autophosphorylation on Ser-729. SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.

产品使用声明
质量保证	Routinely evaluated by phosphorylation of PKC Substrate Peptide
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	6 months at -70°C

包装信息
数量	10 µg
包装	2 vials at 5μg each Also available in 250μg size (2x125μg)--call for pricing and availability and reference catalog number 14-518M when ordering the 250μg size.

merck millipore,默克密理博,14-518,PKCε Protein, active, 10 µg

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