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描述 产品目录编号 14-377M 品牌系列 Upstate
商名 - Upstate
描述 MKK4/SKK1 Protein, active, 250 µg 概述 N-terminal GST tagged, murine MKK4 residues 34-end 应用 应用 Active, N-terminal GST tagged, murine MKK4 residues 34-end, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 expressed in E. coli 品种 Mouse 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_003010.2
Entrez基因汇总 This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. 基因符号 - PRKMK4
- MAP2K4
- MKK4
- JNKK
- MEK4
- MAPKK4
- JNKK1
- SEK1
- SERK1
蛋白靶 MKK4 纯化方法 Purified using glutathione agarose. Activated by incubation with MEKK and then re-purified using Ni2+/NTA agarose 靶子系列 STE UniProt编号 - P45985
UniProt汇总 FUNCTION: SwissProt: P45985 # Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1).
SIZE: 399 amino acids; 44288 Da
SUBUNIT: Interacts with SPAG9 (By similarity).
TISSUE SPECIFICITY: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
PTM: Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases (By similarity).
SIMILARITY: SwissProt: P45985 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of ATF2 substrate 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70C 包装信息 数量 250 µg 包装 Also available in 10 μg size (cat#14-377) and in bulk (cat# 14-377-K).
上一件merck millipore产品：merck millipore,默克密理博,AB15412,Anti-MAP1LC3 A Antibody
下一件merck millipore产品：merck millipore,默克密理博,475741,MAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem
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