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merck millipore,默克密理博,475741,MAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem
产品名称：MAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem
产品型号：475741
The MAGL Inhibitor III, JZL184, also referenced under CAS 1101854-58-3, controls the biological activity of MAGL.
merck millipore,默克密理博,475741,MAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem
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重要规格表
经验配方 CAS号 C₂₇H₂₄N₂O₉ 1101854-58-3 描述 概述 A cell-permeable, blood-brain-barrier-permeant, and orally available carbamate compound that selectively inhibit MAGL (monoacylglycerol lipase) activity over FAAH (fatty acid amide hydrolase) and 35 other murine brain serine hydrolases, both in vitro (IC50 = 6 - 8 nM against 2-AG hydrolysis by MAGL vs. 4 µM against anandamide/AEA hydrolysis by FAAH) and in mice in vivo (5-fold 2-AG enhancement and 75% MAGL activity inhibition in brain membrane from mice 4 hr after a single JZL184 dosage at 4 mg/kg via i.p.) in an irreversible, time- and dose-dependent manner. A great complement to the FAAH inhibitor URB597 (Cat. No. 341249) in differentiating the roles of CB1 and CB2 (type I and II cannabinoid receptors) in eCB- (endocannabinoid) mediated cellular signaling and in vivo physiological effects. Reported to be equally effective against human and murine MAGL, but inhibit rat MAGL with a ~10-fold lower potency. 产品目录编号 475741 品牌系列 Calbiochem®
同义词 4-Nitrophenyl-4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate, Monoacylglycerol Lipase Inhibitor III, JZL184 参考 参考 Nomura, D.K., et al. 2010. Cell 140, 49.
Long, J.Z., et al. Nature Chem. Biol. 16, 744.
Long, J.Z., et al. 2009. Nature Chem. Biol. 5, 37.
Pan, B., et al. 2009. J. Pharmacol. Exp. Ther. 331, 591.产品信息 CAS号 1101854-58-3 形式 White solid Hill配方 C₂₇H₂₄N₂O₉ 化学配方 C₂₇H₂₄N₂O₉ Molar Mass 520.5 结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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