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品种反应性 主要应用 宿主 格式 抗体类型 R, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB15097 描述 Anti-mGluR4 Antibody Alternate Names - glutamate receptor, metabotropic 4
- glutamate metabotropic receptor 4
- glutamate receptor
背景信息 L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. 产品信息 格式 Purified 控制 - Mouse Brain Lysate.
演示 Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3. 应用 应用 This Anti-mGluR4 Antibody is validated for use in WB for the detection of mGluR4. 主要应用 - Western Blotting
生物信息 免疫原品种 Recombinant Protein. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Cat. # AB15097 recognizes mGluR4 (GRM4). 品种反应性 RatMouse Species Reactivity Note Mouse and Rat. Reactivity with other species has not been determined. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001013403.1
基因符号 - mGluR4
- GPRC1D
- MGLUR4
- mGlu4
纯化方法 Antigen affinity purified UniProt编号 - Q68EF4
UniProt汇总 FUNCTION: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity By similarity.
SUBUNIT STRUCTURE: Interacts with PICK1 By similarity.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 3 family.
产品使用声明 质量保证 Western Blot:
Mouse Brain Lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8ºC from date of receipt. 包装信息 数量 50 µg
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