merck millipore,默克密理愽
  • merck millipore,默克密理博,GF120,Osteoprotegerin Protein, Recombinant human

  • merck millipore,默克密理博,GF120,Osteoprotegerin Protein, Recombinant human

    产品名称：Osteoprotegerin Protein, Recombinant human
    产品型号：GF120
    The Human OPG protein (or Osteoprotegerin protein), also know as OCIF (Osteoclastogenesis inhibitory factor), is a member of the TNF receptor superfamily.

    merck millipore,默克密理博,GF120,Osteoprotegerin Protein, Recombinant human

  • 产品介绍
  • merck millipore,默克密理博,GF120,Osteoprotegerin Protein, Recombinant human

    重要规格表

    主要应用 品种 来源 纯度
    CULTHumanE.coliGreater than 98% by SDS-PAGE and FPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of OPG.
    描述
    产品目录编号 GF120
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Osteoprotegerin Protein, Recombinant human
    概述 Human OPG (Osteoprotegerin, also know as OCIF (Osteoclastogenesis inhibitory factor), is a member of the TNF receptor superfamily. Recombinant human OPG/OCIF specifically acts on bone tissues and increases bone mineral density and bone volume associated with a decrease of active osteoclast number. Chemicon's recombinant human OPG is a 19.9 kDa protein, containing 175 amino acid residues, comprising the extra-cellular domain of OPG.
    Alternate Names
    • OPG
    产品信息
    演示 The sterile filtered solution was lyophilized from 10 mM Tris, pH 7.5 + 75 mM NaCl.
    应用
    应用 The Human OPG protein (or Osteoprotegerin protein), also know as OCIF (Osteoclastogenesis inhibitory factor), is a member of the TNF receptor superfamily.
    主要应用
    • Cell Culture
    生物信息
    纯度 Greater than 98% by SDS-PAGE and FPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of OPG.
    来源 E.coli
    品种 Human
    特异活性 Determined by its ability to neutralize the stimulation of U937 cells treated with 10 ng/ml of soluble RANKL (sRANKL).
    Entrez基因编号
    • NM_002546.3
    Entrez基因汇总 The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
    基因符号
    • TR1
    • TNFRSF11B
    • MGC29565
    • OCIF
    • Osteoprotegerin
    • osteoprotegerin
    • OPG
    UniProt编号
    • O00300
    UniProt汇总 FUNCTION: SwissProt: O00300 # Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.
    SIZE: 401 amino acids; 46040 Da
    SUBUNIT: Homodimer.
    SUBCELLULAR LOCATION: Secreted.
    TISSUE SPECIFICITY: Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.
    PTM: N-glycosylated. Contains sialic acid residues. & The N-terminus is blocked.
    DISEASE: "SwissProt: O00300 # Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD) [MIM:239000]; also called hyperostosis corticalis deformans juvenilis or hereditary hyperphosphatasia or chronic congenital idiopathic hyperphosphatasia. JPD is a rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast- mediated skeletal resorption, the disease can be fatal."
    SIMILARITY: SwissProt: O00300 ## Contains 2 death domains. & Contains 4 TNFR-Cys repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 The lyophilized powder is stable for a few weeks at room temperature, but best stored at -20°C. Reconstitute in 5 mM Tris, pH 7.5 to a concentration of 0.1 - 1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use. Reconstituted human OPG should be stored in undiluted aliquots at -20°C. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,GF120,Osteoprotegerin Protein, Recombinant human

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