merck millipore,默克密理愽
  • merck millipore,默克密理博,371706,GPR40 Agonist - CAS 885101-89-3 - Calbiochem

  • merck millipore,默克密理博,371706,GPR40 Agonist - CAS 885101-89-3 - Calbiochem

    产品名称：GPR40 Agonist - CAS 885101-89-3 - Calbiochem
    产品型号：371706
    The GPR40 Agonist, also referenced under CAS 885101-89-3, controls the biological activity of GPR40. This small molecule/inhibitor is primarily used for Cell Signaling applications.

    merck millipore,默克密理博,371706,GPR40 Agonist - CAS 885101-89-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,371706,GPR40 Agonist - CAS 885101-89-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₂H₂₁NO₃885101-89-3
    描述
    概述 A cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GPR40 (EC50 ~50 nM) with much reduced activity towards family members GPR120 (EC50 ~3.5 µM), GPR41/GPR43 (EC50 >50 µM), as well as a panel of eight other fatty acid and prostaglandin receptors. Shown to induces GPR40-dependent Ca2+ mobilization in HEK-293 cells and potentiate glucose-stimulated insulin secretion in MIN6 cells. Reported to exhibit an in vivo half-life of ≥5.3 hr. in rat (p.o. or i.v.) with a bioavailability of 65% and a clearance of 24.9 ml/min/kg.
    产品目录编号 371706
    品牌系列 Calbiochem®
    同义词 3-(4-(((3-(Phenoxy)phenyl)methyl)amino)phenyl)propanoic acid, FFA1 Agonist I, Free Fatty Acid Receptor 1 Agonist I
    参考
    参考 McKeown, S C., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1584.
    Briscoe, C. P., et al. 2006. Br. J. Pharmacol. 148, 619.
    产品信息
    CAS号 885101-89-3
    形式 Light yellow solid
    Hill配方 C₂₂H₂₁NO₃
    化学配方 C₂₂H₂₁NO₃
    Molar Mass 347.4
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,371706,GPR40 Agonist - CAS 885101-89-3 - Calbiochem

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