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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB, ELISA Rb Purified Polyclonal Antibody 描述 产品目录编号 AB1426 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Uncoupling Protein 1 Antibody Alternate Names - UCP1
产品信息 格式 Purified 演示 Protein A-purified rabbit immunoglobulin. Liquid. Buffer = 100 mM KHPO4, 140 mM NaCl, pH 7. Contains no preservatives. 应用 应用 This Anti-Uncoupling Protein 1 Antibody is validated for use in ELISA, WB for the detection of Uncoupling Protein 1. 主要应用 - Western Blotting
- ELISA
应用说明 ELISA: 1:100,000
Western blot: 1:1,000
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide corresponding to amino acids 145-159 of mouse UCP1. (C)SHLHGIKPRYTGTYN 宿主 Rabbit 特异性 Reactive with mouse, rat, and human UCP1. Reactivity confirmed by western blot of purified UCP from brown adipose tissue. No cross-reactivity with UCP2. 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_021833.3
Entrez基因汇总 Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. 基因符号 - SLC25A7
- UCP1
- Thermogenin
- UCP
UniProt编号 - P25874
UniProt汇总 FUNCTION: SwissProt: P25874 # UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
SIZE: 307 amino acids; 33005 Da
SUBUNIT: Acts as a dimer forming a proton channel.
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Brown adipose tissue.
SIMILARITY: SwissProt: P25874 ## Belongs to the mitochondrial carrier family. & Contains 3 Solcar repeats.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20 in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µL
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下一件merck millipore产品：merck millipore,默克密理博,CBL453F,Anti-CD14 Antibody, conjugated, clone UCHM-1, FITC conjugated
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