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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB5789 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Calcium Channel β 4 Antibody 产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in PBS containing 0.08% sodium azide. 应用 应用 This Anti-Calcium Channel Antibody, β 4 is validated for use in WB for the detection of Calcium Channel. 主要应用 - Western Blotting
应用说明 Immunoblotting: 5-10 μg/mL. Reacts with the 55 kD protein.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide from rat beta4 calcium channel. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 beta4 calcium channel (Voltage-Dependant L-type Calcium Channel, beta4 subunit). 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001005747.1
- NM_000726.2
- NM_001005746.1
Entrez基因汇总 This gene encodes a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. 基因符号 - EJM
- CACNB4
- EA5
- CACNLB4
- CAB4
UniProt编号 - O00305
UniProt汇总 FUNCTION: SwissProt: O00305 # The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
SIZE: 520 amino acids; 58169 Da
SUBUNIT: The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma.
TISSUE SPECIFICITY: Expressed predominantly in the cerebellum and kidney.
DISEASE: SwissProt: O00305 # Defects in CACNB4 are a cause of idiopathic generalized epilepsy (IGE) [MIM:600669]. IGE is characterized by recurrent generalized seizures. & Defects in CACNB4 are a cause of juvenile myoclonic epilepsy (JME) [MIM:606904]. JME is a common epileptic syndrome characterized by afebrile seizures, onset in adolescence (rather than in childhood) and myoclonic jerks.
SIMILARITY: SwissProt: O00305 ## Belongs to the calcium channel beta subunit family. & Contains 1 SH3 domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,529625,Polyphosphoinositide-Binding Peptide, PBP10 - Calbiochem
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