merck millipore,默克密理博,529625,Polyphosphoinositide-Binding Peptide, PBP10

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Merck Millipore 默克密理愽

merck millipore,默克密理博,529625,Polyphosphoinositide-Binding Peptide, PBP10 - Calbiochem

经验配方
C₈₄H₁₂₇N₂₄O₁₅

描述
概述	A Rhodamine-B-labeled decapeptide derived from the (PIP₂)-binding region in segment-2 of gelsolin. Acts as a cell-permeable, reversible, and non-toxic agent that transiently disrupts actin filaments, which are essential for cell morphology and cell motility (~1-10 µM). Specifically binds to polyphosphoinositide (PPI) with high affinity and activates platelet without significantly affecting intracellular Ca²⁺ influx. Undergoes a reduction in fluorescence intensity upon binding to phosphatidylinositol 4,5-bisphosphate (PIP₂) and lysophosphatidic acid; the fluorescence is not affected in the presence of phosphatidylserine and phosphatidylcholine. Useful fluorescent probe for the cellular localization and stabilization of PPIs.
产品目录编号	529625
品牌系列	Calbiochem®
同义词	RhoB-GS_160-169, Rhodamine B-QRLFQVKGRR-OH

参考
参考	Bucki, R., et al. 2001. Biochemistry 40, 15752 Cunningham, C.C., et al. 2001. J. Biol. Chem. 276, 43390.

产品信息
具有ATP竞争性	N
形式	Pinkish red lyophilized solid
配方	Supplied as a trifluoroacetate salt.
Hill配方	C₈₄H₁₂₇N₂₄O₁₅
Molar Mass	1713.1
吸湿	Hygroscopic
肽序列	Rho-B-Gln-Arg-Leu-Phe-Gln-Val-Lys-Gly-Arg-Arg-OH
可逆	Y

生物信息
主靶	Specifically binds to polyphosphoinositide (PPI)
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y
最大排放	590 nm
最大激励	565 nm
溶解度	DMSO
肽序列	Rho-B-Gln-Arg-Leu-Phe-Gln-Val-Lys-Gly-Arg-Arg-OH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,529625,Polyphosphoinositide-Binding Peptide, PBP10 - Calbiochem

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