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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABE798 描述 Anti-KPNA6 Antibody Alternate Names - Karyopherin subunit alpha-6
- Importin subunit alpha-7
背景信息 Importin subunit alpha-7, also known as Karyopherin subunit alpha-6, and encoded by the gene name KPNA6 or IPOA7, is a member of the Importin alpha family. KPNA6 is a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Randependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. 应用 应用 Detect KPNA6 using this Anti-KPNA6 Antibody validated for use in western blotting & immunofluorescence. 主要应用 - Western Blotting
应用说明 Immunofluorescence Analysis: 20 μg/mL from a representative lot detected KPNA6 in HEK293 cells. 生物信息 免疫原品种 KLH-conjugated synthetic peptide corresponding to the N-terminus of human KPNA6. 表位 N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody is predicted to not cross-react with other Importin alpha family members. 品种反应性 Human 抗体类型 Polyclonal Antibody 基因符号 - IPOA7
- KPNA6
纯化方法 Antigen Affinity purified UniProt编号 - O60684
产品使用声明 质量保证 Evaluated by Western Blotting in HEK293 cell lysate.
Western Blotting Analysis: 1 μg/mL of this antibody detected KPNA6 in HEK293 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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