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品种反应性 主要应用 宿主 格式 抗体类型 M IHC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB10535 描述 Anti-Neurogenin-3 (rabbit) Antibody Alternate Names - Neurogenin3
- Neurogenin 3
- NGN3
背景信息 Neurogenins are a family of bHLH transcription factors involved in specifying neuronal differentiation. They are related to Drosophila atonal. The neurogenins (ngns) make up one of these atonal-related gene families. In neural crest cells, the atonal-related neurogenin family is particularly important for the sensory lineage (Neurogenins Are Essential for the Formation of dorsal root ganglia), while the achaete-scute homologue ash1 (Mash1) is important for aspects of autonomic neurogenesis (mash1 is essential for noradrenergic differentiation). Neurogenin-3 also promotes pancreatic development. 产品信息 格式 Serum 控制 - mNgn3 transfected and wildtype rabbit reticulocyte lysates
演示 Unpurified rabbit polyclonal serum containing 0.05% sodium azide. 应用 应用 Detect Neurogenin-3 (rabbit) using this Anti-Neurogenin-3 (rabbit) Antibody validated for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:500 dilution from a previous lot detected Neurogenin-3 in mouse embryo E12.5+ tissue. 生物信息 免疫原品种 GST-tagged recombinant protein corresponding to the N-terminus of mouse Neurogenin-3. 表位 N-terminus 宿主 Rabbit 特异性 This antibody recognizes Neurogenin-3 at the N-terminus. 同种型 IgG 品种反应性 Mouse Species Reactivity Note Demonstrated to react with mouse. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_033849
基因符号 - Math4B
- NEUROG3
- ATOH5
- Atoh5
- ngn3
- NGN3
- MATH4B
纯化方法 Unpurified UniProt编号 - P70661
UniProt汇总 FUNCTION: Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types.
SUBUNIT STRUCTURE: Efficient DNA binding requires dimerization with another bHLH protein.
SUBCELLULAR LOCATION: Nucleus Potential.
SEQUENCE SIMILARITIES: Contains 1 basic helix-loop-helix (bHLH) domain.产品使用声明 质量保证 Evaluated by Western Blot in mNgn3 transfected and wildtype rabbit reticulocyte lysates.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected Neurogenin-3 on 10 µg of mNgn3 transfected rabbit reticulocyte lysates.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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