merck millipore,默克密理愽
  • merck millipore,默克密理博,SF-1077,VHL; Human, Cyanine 3, RNA Detection Probe,SmartFlare

  • merck millipore,默克密理博,SF-1077,VHL; Human, Cyanine 3, RNA Detection Probe,SmartFlare

    产品名称：VHL; Human, Cyanine 3, RNA Detection Probe, SmartFlare
    产品型号：SF-1077
    Use SmartFlare RNA Detection probes to measure gene expression in live cells. With an overnight incubation of SmartFlare VHL, Human, Cyanine 3, you can detect VHL RNA levels within your cells.

    merck millipore,默克密理博,SF-1077,VHL; Human, Cyanine 3, RNA Detection Probe,SmartFlare

  • 产品介绍
  • merck millipore,默克密理博,SF-1077,VHL; Human, Cyanine 3, RNA Detection Probe,SmartFlare

    重要规格表

    Entrez Gene Number Species Reactivity Species Reactivity Note
    NM_000551.3HNM_198156.2
    描述
    产品目录编号 SF-1077
    商名
    • SmartFlare
    描述 VHL; Human, Cyanine 3, RNA Detection Probe | SmartFlare
    Alternate Names
    • pVHL
    • RCA1
    • VHL1
    背景信息 With SmartFlare™ RNA Detection probes, you can detect RNA in LIVE CELLS with ease. With just an overnight incubation of VHL; Human, Cyanine 3, RNA Detection Probe you can detect the presence of VHL within your cells.
    Von Hippel-Lindau disease is a rare tumor syndrome that is characterized by cerebellar and spinal hemangioblastomas and retinal angiomas. Molecular studies suggest that VHL is a tumor suppressor gene, which is inactivated or mutated in von Hippel-Lindau disease as well as in clear-cell renal carcinomas (RCC). The gene is affected in both hereditary and in sporadic tumors. In clear-cell renal carcinomas there is loss of function of both copies of the gene suggesting a role in proliferation control. This hypothesis is borne out by the observation that transfection of the wild type protein will inhibit cell growth. Initially identified in 1993, the VHL protein has a bipartite localization, it is found localized to the cytoplasm in densely cultured cells but in the nucleus in sparse cell cultures. The primary functional target of VHL protein is the transcription elongation complex in particular, the elongin proteins B and C which bind in vitro and in vivo to a short, colinear region of the VHL protein that is frequently mutated in human tumors. In addition to the elongins, VHL has been shown to bind to other proteins including the HIV tat-binding protein, filamin and VBP-1, and two other VHL binding proteins, p14 (p16) and p10 (p9). More recently, VHL has been shown to control VEGF expression in several different tumors, affecting primarily the splice variants VEGF121 and VEGF165.
    产品信息
    格式 Cyanine 3
    演示 Lyophilized
    应用
    应用 Use SmartFlare RNA Detection probes to measure gene expression in live cells. With an overnight incubation of SmartFlare VHL, Human, Cyanine 3, you can detect VHL RNA levels within your cells.
    主要应用
    • RNA Detection
    生物信息
    品种反应性 Human
    Species Reactivity Note NM_198156.2
    Entrez基因编号
    • NM_000551.3
    基因符号
    • VHL
    产品使用声明
    质量保证 SmartFlare Probes have been tested in a buffer system to detect the release of the fluorophore in the presence of a complimentary base pair sequence for each lot to confirm target specificity. SmartFlare Probes have also been tested in a cell model system and demonstrated increased fluorescence in cells expressing the target compared to a negative SmartFlare Scramble Control.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at 2–8°C in lyophilized format ONLY. Room temperature is required for reconstituted product.
    包装信息
    数量 250 reactions

    merck millipore,默克密理博,SF-1077,VHL; Human, Cyanine 3, RNA Detection Probe,SmartFlare

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