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merck millipore,默克密理博,681677,Wnt Pathway Inhibitor XII - Calbiochem
产品名称:Wnt Pathway Inhibitor XII - Calbiochem
产品型号:681677
The Wnt Pathway Inhibitor XII controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications.
merck millipore,默克密理博,681677,Wnt Pathway Inhibitor XII - Calbiochem
- 产品介绍
重要规格表
经验配方 C₁₆H₁₅F₂N 描述 概述 A cell-permeable fluorinated N,N-dialkylaminostilbene (FIDAS) compound that inhibits MAT2A-catalyzed SAM (S-adenosylmethionine) synthesis by targeting SAM-binding pocket at the MAT2A dimer interface. Shown to downregulate intracellular SAM level (by 64%; 36 h;10 µM) and Wnt signaling in LS174 colorectal cancer cultures and is at least 10-fold more potent than Pterostilbene (Cat. No. 523310) and Resveratrol (Cat. No. 554325) in inhibiting LS174 proliferation both in vitro (by 90% in 4 d; 1 µM) and in mice in vivo (by 75% on d26; 20 mg/kg/day; i.p.). 产品目录编号 681677 品牌系列 Calbiochem®
同义词 (E)-4-(2,6-Difluorostyryl)-N,N-dimethylaniline, FIDAS3, MAT2A Inhibitor I, Methionine S-Adenosyltransferase 2A Inhibitor I 参考 参考 Zhang, W., et al. 2013. ACS Chem.Biol. 18, In press.
Zhang, W., et al. 2011. J. Med. Chem. 54, 7579.产品信息 形式 Off-white to pale yellow solid Hill配方 C₁₆H₁₅F₂N 化学配方 C₁₆H₁₅F₂N Molar Mass 259.3 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Regulatory Review
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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