• merck millipore,默克密理博,681677,Wnt Pathway Inhibitor XII - Calbiochem
  • merck millipore,默克密理博,681677,Wnt Pathway Inhibitor XII - Calbiochem

    产品名称:Wnt Pathway Inhibitor XII - Calbiochem
    产品型号:681677
    The Wnt Pathway Inhibitor XII controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications.

    merck millipore,默克密理博,681677,Wnt Pathway Inhibitor XII - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,681677,Wnt Pathway Inhibitor XII - Calbiochem

    重要规格表

    经验配方
    C₁₆H₁₅F₂N
    描述
    概述 A cell-permeable fluorinated N,N-dialkylaminostilbene (FIDAS) compound that inhibits MAT2A-catalyzed SAM (S-adenosylmethionine) synthesis by targeting SAM-binding pocket at the MAT2A dimer interface. Shown to downregulate intracellular SAM level (by 64%; 36 h;10 µM) and Wnt signaling in LS174 colorectal cancer cultures and is at least 10-fold more potent than Pterostilbene (Cat. No. 523310) and Resveratrol (Cat. No. 554325) in inhibiting LS174 proliferation both in vitro (by 90% in 4 d; 1 µM) and in mice in vivo (by 75% on d26; 20 mg/kg/day; i.p.).
    产品目录编号 681677
    品牌系列 Calbiochem®
    同义词 (E)-4-(2,6-Difluorostyryl)-N,N-dimethylaniline, FIDAS3, MAT2A Inhibitor I, Methionine S-Adenosyltransferase 2A Inhibitor I
    参考
    参考 Zhang, W., et al. 2013. ACS Chem.Biol. 18, In press.
    Zhang, W., et al. 2011. J. Med. Chem. 54, 7579.
    产品信息
    形式 Off-white to pale yellow solid
    Hill配方 C₁₆H₁₅F₂N
    化学配方 C₁₆H₁₅F₂N
    Molar Mass 259.3
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Regulatory Review
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,681677,Wnt Pathway Inhibitor XII - Calbiochem

上一件merck millipore产品:merck millipore,默克密理博,MAB3828,Anti-Mucin 5B Antibody, clone 15.5B
下一件merck millipore产品:merck millipore,默克密理博,MAB319,Anti-Chromogranin A Antibody, clone PHE5



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